April 3, 2026
AI agents replicate 20% of YC startups, raising questions about defensibility. Plus, an AI super-connector and a critique of Apple's innovation.
April 2, 2026
AI's next frontier: CEOs discuss specialized tabular models, interactive video, and the photonic interconnects powering the $10B future.
April 1, 2026
Venture roundtable on SpaceX's IPO, AI's public trust crisis, the defense tech bubble, and why top entrepreneurs avoid introspection.
March 31, 2026
Build autonomous AI agents that improve while you sleep. This episode provides a 5-step framework for OpenClaw, plus demos of agent tools.
March 27, 2026
Astroforge's plan to mine asteroids, Templar's decentralized AI training, and a look at the economics of rebooting massive movie franchises.
March 26, 2026
This episode explores three Bittensor subnets creating real-world value in drug discovery (Metanova), the creator economy (BitCast), and AI vision (Score).
March 25, 2026
Experts from Gecko Robotics & Modular discuss purpose-built robots, the AI chip war, NVIDIA's dominance, and the future of American AI.
March 24, 2026
A deep dive into the Delve compliance scandal, founder integrity, AI's impact on VCs, and the disruptive potential of Bittensor (Tau).
March 20, 2026
Zipline's Keller Clifton on scaling drone delivery from Rwanda to the US & Superhuman's Raul Vora on his journey from inception to acquisition.
March 18, 2026
Robinhood CEO Vlad Tenev shares insights on disrupting finance with a free model, leveraging viral growth, and integrating AI to scale.
March 16, 2026
This episode explores the future of human augmentation, aviation, and wellness with founders from Paradromics (BCIs), Jet Zero, and Nutrisense.
March 14, 2026
This episode explores decentralized cloud storage with BitTensor's Hippias and the viral marketing success of the single-offering coffee brand, FWFO.
March 11, 2026
Experts discuss the AV industry's shift from tech hurdles to scaling, complex fleet management, city-by-city safety validation, and public trust.
Exploring Karpathy's self-improving AI, public fear of AI job loss, and demos of agents transforming banking and mobile automation.
March 6, 2026
The future of AI is decentralized. This episode dives into BitTensor ($TAO), a crypto network incentivizing AI development at a fraction of the cost.
March 5, 2026
TWiST explores Anthropic's Pentagon clash, the OpenClaw explosion, stablecoin strategies, and demos new tools for the agentic web.
March 3, 2026
Dave Morin on bullet-proofing the OpenClaw foundation, the agentic AI investment landscape, and the challenges for startups in a rapidly evolving ecosystem.
February 28, 2026
OpenAI's record funding, Block's AI-driven layoffs, J-curves explained, and innovative founder demos. A deep dive into AI's disruptive force.
February 26, 2026
Exploring OpenClaw's impact, the Anthropic vs. Pentagon AI ethics debate, SaaS disruption, and demos of new agent hardware and APIs.
February 24, 2026
Explore OpenClaw's power with Oliver Henry & Jeff Weisbein. Learn to automate marketing & development, boosting efficiency & challenging SaaS models.
February 21, 2026
Experts reveal how to maximize OpenClaw value, from simplifying setup for beginners to building multi-agent systems and real-world integration.
February 19, 2026
When will OpenClaw go mainstream? Experts debate the hurdles: it's too technical, lacks a killer consumer app, and poses significant security risks.
February 17, 2026
OpenAI's acquisition of OpenClaw sparks debate on its future. Guests demo its power with custom apps, fueling a call to keep the ecosystem open.
February 14, 2026
Founders showcase OpenClaw innovations: AntFarm for agent orchestration, Clara the virtual companion, and Rent a Human for AI-powered tasks.
February 12, 2026
Jason Calacanis backs his former employee’s health app, Tempo, and interviews Sorcerer, an AI platform disrupting global procurement.
Founders demo how OpenClaw's agentic AI automates workflows, integrates with hardware, and slashes startup costs, leading to on-air investments.
February 10, 2026
This Week in Startups explores the OpenClaw revolution with guests Alex Finn & Matt Van Horn, covering AI agents, local vs cloud, and the future of work.
February 7, 2026
Building OpenClaw Ultron to replace 20 jobs by automating workflows with local LLMs, focusing on data sovereignty and productivity gains.
February 4, 2026
HQ Trivia's Scott Rogowsky launches Savvy, a live Wordle-style game. Plus, Starfish Space on building the 'blue collar' service economy for satellites.
February 3, 2026
Early-stage founders must prioritize product, customer obsession, and trust before fundraising. Build a business, not just a pitch deck.
SpaceX acquires xAI to build AI compute in space. Plus, a deep dive into OpenClaw, the open-source AI agent revolutionizing workflows.
January 31, 2026
AI agents like OpenClaw are revolutionizing business workflows, offering massive productivity gains while introducing critical security risks.
January 29, 2026
Cannabis experts discuss the startup boom driven by decriminalization, the hemp loophole, investment trends, and the path to federal legalization.
January 27, 2026
Experts unpack Clawdbot, a powerful open-source AI agent automating businesses, writing code, and learning, signaling an inflection point.
January 24, 2026
AI is disrupting healthcare, becoming the primary care doctor. Japan's startup scene is booming in deep tech, defense, and unique social apps.
January 21, 2026
Zipline CEO Keller Clifton on scaling automated delivery from life-saving medical supplies to US home delivery, powered by a massive new factory.
January 20, 2026
Globis Capital's Shin Takamiya discusses Japan's startup boom, where entrepreneurship has become 'cool,' attracting top talent from traditional jobs.
January 16, 2026
Angel investor Thomas McInerney on his playbook: back technical founders, avoid buzzwords, stay frugal, and think bigger than your niche.
January 14, 2026
mPower Partners' Kathy Matsui discusses Japan's startup revolution, Uniqlo's global strategy, and the nation's shifting economic landscape.
January 13, 2026
This episode explores Boom Supersonic's origin story and a startup using AI to collect government fraud bounties. Plus, tips on building teams.
Ex-Uber recruiter Sho Takei reveals startup hiring secrets in the US vs. Japan, covering cultural differences, AI, and remote work debates.
January 10, 2026
The IPO market is back with Discord & Strava! This episode covers Anthropic's massive new valuation and the top robotics & AI tech from CES 2026.
January 8, 2026
AI Roundtable: Steven Johnson & Grant Lee argue AI enhances creativity & productivity, transforming knowledge work despite public skepticism.
January 6, 2026
NVIDIA's $20B Grok deal & Meta's $2.5B Butterfly buy signal an AI M&A boom. Plus, Yann LeCun's Meta exit & AI's impact on legal tech.
December 30, 2025
This Week in Startups presents the 2025 'Twisties,' awarding the year's best trends, guests, rants, and controversial moments in tech.
December 29, 2025
Jason Calacanis on managing VC inbound, the value of European capital, avoiding extravagant purchases, and the future of vertical AI applications.
December 23, 2025
Waymo's SF power outage failure contrasts with Tesla's FSD vision. This episode covers AI's rapid growth, the future of robo-taxis, and M&A.
December 20, 2025
Sam Parr shares timeless copywriting secrets. Learn why long-form copy, simple language, and compelling storytelling are crucial for founders.
December 18, 2025
AI leaders from Zapier, Suno & Micro One on the talent war, the new frontier of training data, and why AI agents are the decade's challenge.
December 16, 2025
The Invest Act passed, democratizing venture capital. AI accelerates job displacement, mega-funds like Lightspeed's $9B grow, and iRobot fails.
December 13, 2025
Disney's $1B OpenAI deal sets a new IP precedent for AI, as a new executive order fuels the debate on automation, jobs, and regulation.
December 11, 2025
Venture capitalists debate the AI bubble, high valuations, and exit strategies, concluding product velocity is the new moat in a frothy market.
December 10, 2025
This episode covers Tour's AI video for real estate, Alembic's causal AI for marketing, and a 2016 look at Zapier's vision for automation.
December 9, 2025
This week: OpenAI's ad controversy, the strategic value of startup code reds, and the high-stakes bidding war for Warner Bros. Discovery.
December 6, 2025
Netflix's $72B WB deal sparks debate on Hollywood's future. Plus: AI's copyright crisis, insider trading on prediction markets, and new YC bets.
December 4, 2025
Thumbtack & Athena founder Jonathan Swanson on building unicorns, the power of delegation, and leveraging human + AI assistants to achieve time abundance.
December 3, 2025
This episode explores hardware automation with Monumental's bricklaying robots and CSATS' autonomous sea drones, tackling real-world problems.
December 2, 2025
Unpacking MicroStrategy's meltdown & Tether's risk downgrade. Plus, David Sacks' DC role debate & the rise of 'glue employees' and home robots.
November 26, 2025
Applied AI is transforming IT ops and education, while a look back at Scale AI reveals the foundational importance of data.
November 24, 2025
Familify's pivot to Theo shows data's power. OnVerite automates due diligence, & Pitch Perfect nails SMS sales. A masterclass in growth.
November 22, 2025
Google's Gemini is winning the consumer AI race against OpenAI. We break down Nvidia's strong earnings, the GPU depreciation debate, and M&A predictions.
November 20, 2025
Mistral AI's enterprise strategy, the AI music legal battle, and why the FTC's loss against Meta signals a new M&A frenzy for tech giants.
November 19, 2025
The AI race accelerates with Grok 4.1 & Gemini 3. Microsoft & Nvidia bet billions on Anthropic, raising urgent questions about AI's impact on jobs.
November 18, 2025
Jeff Bezos returns as co-CEO of a $6.2B AI startup. Jason discusses global tech hubs, Ramp's valuation soars, and a Waymo incident sparks debate.
November 14, 2025
Knox's AI tackles inbox overload, Alloy Automation builds AI agents for business, and Shopify's origin story offers timeless startup lessons.
November 13, 2025
From space tugs and AI's past to Robinhood's viral launch, this episode explores the tech frontier's past, present, and future.
November 11, 2025
Interviews with Harvey AI (legal tech) & OpenRouter (LLM routing), plus Jason on building defensible moats in a copycat world.
November 10, 2025
AI job displacement is imminent, fueling a new wave of entrepreneurship amid a tech bubble. Meanwhile, high-growth startups are scaling toward IPO.
November 6, 2025
VCs dissect Sequoia's leadership change, the AI boom's impact on valuations, and why the bar for pre-seed startup funding is higher than ever.
November 3, 2025
This Week in Startups covers OpenAI's $1.4T spend and market contagion risk, new AI liability rules, and the perils of building in public.
November 1, 2025
This week: A stark warning on OpenAI's platform risk, demos of Suno's music AI, cloud earnings analysis, and the ethics of founder-investor trust.
October 30, 2025
TWiST covers 37signals' sabbaticals, Superhuman's major rebrand, OpenAI's new structure, Nvidia's $5T valuation, and the rise of robotics.
October 29, 2025
This week features founders building the future: SpatialGen's spatial cloud, Hux's personal audio AI, and Chess Ever's pro-level platform.
