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  1. This Week in Startups
  2. How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241
How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups · Jan 29, 2026

Cannabis experts discuss the startup boom driven by decriminalization, the hemp loophole, investment trends, and the path to federal legalization.

Regulatory Downturns Forge Resilient Companies by Forcing Resourcefulness

The current challenging market forces cannabis startups to be incredibly resourceful, mirroring the industry's long history of operating in grey or illicit markets. This "survival of the fittest" environment ultimately strengthens the best companies.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

Sparkplug Boosts Retailer Margins by Letting Brands Fund Employee Raises

Sparkplug's software lets brands pay commissions directly to retail employees. Retailers benefit from reduced turnover by offering a de facto raise funded entirely by brand marketing budgets, not their own payroll.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

Cannabis Investors Face an Arbitrage Opportunity Before Federal Rescheduling

Regulatory uncertainty has depressed valuations for brands that burned capital fighting state-level rules. This creates an arbitrage window for investors to acquire established brands at a discount before federal rescheduling unlocks their true market potential and valuations rebound.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

Illicit Market Economics Drive High Potency Cannabis, Similar to Moonshine

The demand for extremely high-THC cannabis is a direct consequence of prohibition and over-regulation. Just as alcohol prohibition led to moonshine, when consumers take risks or pay high taxes, they demand the most potent product for their money, skewing the market.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

Jane's E-commerce Model Digitizes Local Stores to Compete with Amazon

Jane's strategy avoids direct competition with Amazon by digitizing existing brick-and-mortar retail inventory. This creates an "Amazon-like" online experience for consumers but funnels value back into local economies, a model applicable to groceries, alcohol, and other regulated goods.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

Tax Code 280E Cripples Cannabis Firms with 60-70% Effective Tax Rates

Because cannabis is a Schedule I drug, tax code 280E prevents businesses from deducting standard operating expenses, resulting in crippling effective tax rates. Federal rescheduling would eliminate this, instantly making many struggling companies profitable overnight.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

Cannabis-Induced Psychosis May Be Misdiagnosed Pesticide Toxicity from Neem Oil

A rare cannabis-induced nausea condition has symptoms identical to neem oil toxicity. As lab tests show prevalent neem oil contamination in cannabis products, negative health effects attributed to high-THC cannabis might actually be caused by the pesticides used to grow it.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

US Cannabis Market's Patchwork Rollout Creates Pent-Up Infrastructure

Unlike Canada's top-down legalization, the US's state-by-state approach has built significant, isolated infrastructure. Federal approval would unleash this capacity for interstate commerce, allowing production to consolidate in ideal locations and dramatically reshaping the national supply chain.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago

The 2018 Farm Bill's Hemp Loophole Enabled CPG-Style Growth for Cannabis Brands

The bill federally legalized hemp, creating a loophole for brands to legally ship THC products direct-to-consumer and run normal CPG ads. This gave hemp-based companies a massive efficiency advantage over state-regulated operators burdened by taxes and marketing restrictions.

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241 thumbnail

How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

This Week in Startups·22 days ago