Prioritizing a candidate's skills ('capacity') over their fit with the team ('chemistry') is a mistake. To scale culture successfully, focus on hiring people who will get along with their colleagues. The ability to collaborate and integrate is more critical for long-term success than a perfect resume.

When diagnosing a failing department, stop looking for tactical issues. The problem is always the leader, full stop. A great leader can turn a mediocre team into a great one, but a mediocre leader will inevitably turn a great team mediocre. Don't waste time; solve the leadership problem first.

Leaders often feel they must have all the answers, which stifles team contribution. A better approach is to hire domain experts smarter than you, actively listen to their ideas, and empower them. This creates a culture where everyone learns and the entire company's performance rises.

Organizational success depends less on high-profile 'superstars' and more on 'Sherpas'—generous, energetic team players who handle the essential, often invisible, support work. When hiring, actively screen for generosity and positive energy, as these are the people who enable collective achievement.

Delaying key hires to find the "perfect" candidate is a mistake. The best outcomes come from building a strong team around the founder early on, even if it requires calibration later. Waiting for ideal additions doesn't create better companies; early execution talent does.

A common leadership trap is feeling the need to be the smartest person with all the answers. The more leveraged skill is ensuring the organization focuses on solving the right problem. As Einstein noted, defining the question correctly is the majority of the work toward the solution.

Better products are a byproduct of a better team environment. A leader's primary job is not to work on the product, but to cultivate the people and the system they work in—improving their thinking, decision-making, and collaboration.

Resolution Therapeutics' CEO builds his team with leaders from varied backgrounds across different diseases and drug modalities. He believes this diversity creates more robust problem-solving, as challenges that are novel in one area may have been solved in another, enabling faster and more informed decisions.

To scale a high-performing product team, hire individuals who exhibit the same level of ownership and love for the product as the original founders. This means prioritizing a blend of deep curiosity, leadership potential, and an unwavering commitment to execution over a simple skills checklist.