The brain's glymphatic waste clearance system works best at night. Mark Burnett suggests taking his supplement in the evening and sleeping on an incline using a wedge pillow to physically assist this natural drainage process, potentially boosting the supplement's effects.
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To create a fair evaluation, Mark Burnett deliberately maintained his sedentary lifestyle and diet. This ensured any improvements were directly attributable to his supplement, making the product viable for patients unable or unwilling to change their habits.
The standard 5-gram dose of creatine is effective for muscle performance but insufficient to saturate the brain. To leverage creatine's neuroprotective and cognitive-enhancing effects—such as improved function when sleep-deprived or aging—a higher daily dose of 10 to 15 grams is necessary.
Don't use the same lighting all day. In the first 8-9 hours after waking, use bright overhead lights to maximize alertness-promoting chemicals like dopamine. In the afternoon (9-16 hours after waking), dim the overhead lights to support serotonin release, which is better for creative or abstract work. This syncs your environment with your natural neurochemical cycles.
Unlike sedatives, DORA-class sleep aids (Dual Orexin Receptor Antagonists) work by inhibiting wakefulness, creating more natural sleep architecture. Research suggests this may improve the brain's ability to clear beta-amyloid and tau proteins linked to Alzheimer's disease, offering a potential preventative strategy.
The brain clears metabolic waste via the glymphatic system, which functions optimally during sleep-induced inactivity. Research indicates that sleeping on your right or left side, with your head slightly elevated, is the best position to facilitate this crucial cleanup process.
The popular advice to take magnesium for sleep is often flawed. Most common forms of magnesium (like oxide or citrate) do not cross the blood-brain barrier. Since sleep is a brain process, these supplements are unlikely to have a direct effect unless an individual is clinically deficient.
Unlike sedatives like Ambien, a new class of medication (DORAs) works by dialing down the brain's wakefulness chemical (orexin). This allows for naturalistic sleep that is functionally beneficial, proven to increase the brain's cleansing of beta amyloid and tau protein, which are linked to Alzheimer's disease.
Specific auditory patterns can directly impact brain function. Research shows that 40 Hz binaural beats can increase striatal dopamine, a neurotransmitter crucial for motivation and focus. This leads to improved memory, faster reaction times, and better verbal recall. Listening for 30 minutes prior to a work session can prime your brain for high performance.
Beyond long-term supplementation, creatine can be used tactically. Taking a large dose (20-30g) on a day with poor sleep has been shown to completely offset the resulting cognitive deficits, and may even boost mental performance above a normal, well-rested baseline.
Regardless of the primary goal—be it focus, anxiety, or performance—99% of neurofeedback clients report improved sleep as the first noticeable change. This typically occurs within the first 5 to 15 sessions, signaling that the brain is beginning to self-regulate more effectively.
