The core ingredient is a specific, difficult-to-source cultivar of the Ziziphora fruit. Most commercially available versions are hybrids bred for sweetness, not therapeutic effect, highlighting the critical importance of raw material specificity in natural supplements.
To create a fair evaluation, Mark Burnett deliberately maintained his sedentary lifestyle and diet. This ensured any improvements were directly attributable to his supplement, making the product viable for patients unable or unwilling to change their habits.
The brain's glymphatic waste clearance system works best at night. Mark Burnett suggests taking his supplement in the evening and sleeping on an incline using a wedge pillow to physically assist this natural drainage process, potentially boosting the supplement's effects.
Mark Burnett’s first sales came organically after running a Michael J. Fox marathon. Other runners with less severe (Stage 1) Parkinson's saw him (Stage 3) performing better and immediately asked to buy his supplement, demonstrating the power of tangible results as a marketing tool.
Mark Burnett saw functional improvement in six months, going from stage 3 to stage 1 Parkinson's. He validated this progress using the amyloid beta 42/40 blood test, which shows increased plaques in the blood as they drain from the brain, providing a medical metric for efficacy.
As Mark Burnett's supplement helped his body produce its own dopamine, he had to stop taking prescription L-dopa. He advises users to work with their doctors to potentially taper off medications as the body's natural regulation returns, preventing issues caused by an excess of the substance.