Experiments show that transferring a cancer cell's dysfunctional mitochondria—but not its nucleus—into a healthy cell is what induces cancer. This disruptive finding supports the view of cancer as a metabolic disease that can be targeted by starving its mitochondria of fuels like glucose.
The standard 5-gram dose of creatine is effective for muscle performance but insufficient to saturate the brain. To leverage creatine's neuroprotective and cognitive-enhancing effects—such as improved function when sleep-deprived or aging—a higher daily dose of 10 to 15 grams is necessary.
When insulin is low, the body becomes so opposed to fat storage that it produces excess ketones. These ketones, which have caloric value, are then expelled through breath and urine. This process represents an effortless expenditure of calories that would otherwise have to be stored or burned through exercise.
Livestock are fattened with B vitamins to increase their metabolic efficiency, yielding more weight from less feed. For human weight loss, metabolic *inefficiency* is desirable. The widespread fortification of foods with B vitamins may inadvertently make our bodies better at storing calories as fat.
Being in ketosis doesn't just enable fat burning; it actively accelerates it. Human studies show that ketones act as signaling molecules that instruct fat cells to increase their metabolic rate threefold. This creates a significant metabolic advantage for weight loss beyond simply using fat for fuel.
Many clinicians mistakenly believe insulin's main role is blood glucose control. In reality, it's a master hormone signaling every cell—from brain to bone—to store energy. This function is so powerful it can slow the body's overall metabolic rate to prioritize energy storage.
A practical strategy for managing insulin involves eliminating carbs from breakfast and lunch, focusing on protein and fat. Make lunch the day's largest meal to curb evening cravings. This structure allows for dietary flexibility at dinner, making the plan socially sustainable long-term.
Consuming sugary foods before bed leads to high blood glucose, which activates the sympathetic nervous system (fight or flight). This physiological stress state increases heart rate and body temperature, directly opposing the calm, parasympathetic state required for restorative sleep and leading to poor sleep quality.
Calorie restriction alone is unsustainable because high-carb meals spike insulin, which sequesters energy from the blood into storage cells. The brain, which lacks storage capacity, perceives this drop in available energy as a crisis and triggers intense, overriding hunger, even if body fat is abundant.
Research shows the L-BHB form of ketones acts as a signaling molecule to expand major arteries like the aorta. This allows the heart to pump up to 40% more blood per beat with less effort, reducing cardiovascular strain and lowering blood pressure. This presents a promising therapeutic avenue for heart failure.
Female metabolism fluctuates significantly with the ovarian cycle. During the first (follicular) phase, women are highly efficient fat-burners and enter ketosis faster than men. However, in the second (luteal) phase, high progesterone levels act as a powerful hunger hormone, making low-carb diets more challenging.
Long-term, high-dose GLP-1 use leads to diminishing returns and significant muscle loss. A more effective strategy is using micro-doses in 90-day cycles, paired with nutritional coaching. This approach uses the drug as a temporary tool to eliminate carb cravings and establish lasting dietary habits.