The ketogenic diet originated from the centuries-old observation that fasting has powerful neurological effects, including stopping seizures. A physician designed the diet to replicate this metabolic state, allowing patients to gain the brain benefits long-term without the danger of starvation.

Ferriss points to the emerging field of metabolic psychiatry, where dietary intervention is used for severe mental illness. He cites cases where schizophrenia patients, after years of failed medications, get off all prescriptions by adopting a ketogenic diet. This approach stabilizes the brain by providing ketones as a clean energy source.

The standard 5-gram dose of creatine is effective for muscle performance but insufficient to saturate the brain. To leverage creatine's neuroprotective and cognitive-enhancing effects—such as improved function when sleep-deprived or aging—a higher daily dose of 10 to 15 grams is necessary.

The standard 5g dose of creatine is largely absorbed by muscles, especially in active individuals. To achieve cognitive benefits like improved focus under stress, a higher dose of 10g or more is needed to create a "spillover" effect that saturates the brain with the compound.

AG1 made a strategic shift from influencer-led marketing to a science-first approach. The company invested over $10 million in double-blind, placebo-controlled human trials and built campaigns around this scientific validation. This move aims to build deep credibility and differentiate the brand in a crowded, often unsubstantiated market.

Naming the brand "This Works" created a non-negotiable promise to consumers. This forced the company to build its entire marketing and R&D strategy around tangible evidence, including user studies, clinical trials, and neuroscience research, to continuously earn brand trust through "proof-pointing".

In epilepsy treatment, patients often use the ketogenic diet for only 2-5 years. The fact that seizures frequently do not return after stopping the diet suggests it can induce lasting metabolic repairs and heal brain dysfunction, rather than just managing symptoms temporarily.

The brain's glymphatic waste clearance system works best at night. Mark Burnett suggests taking his supplement in the evening and sleeping on an incline using a wedge pillow to physically assist this natural drainage process, potentially boosting the supplement's effects.

As Mark Burnett's supplement helped his body produce its own dopamine, he had to stop taking prescription L-dopa. He advises users to work with their doctors to potentially taper off medications as the body's natural regulation returns, preventing issues caused by an excess of the substance.