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  1. The Tim Ferriss Show
  2. #838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello
#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show · Dec 3, 2025

Tim Ferriss & Kevin Rose discuss bioelectric medicine for anxiety, aphantasia, the future of AI, Alzheimer's prevention, and personal updates.

AI Will Shift Venture Capital Focus from Seed Rounds to Growth Marketing

As AI enables founders to build products in a week for under $500, the need for traditional seed capital for engineering will diminish. The bottleneck—and therefore the need for capital—will shift to winning the intense battle for user attention. VCs will fund marketing war chests instead of just development.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

Aphantasia Reveals Some People Experience Ideas as Feelings, Not Mental Images

Kevin Rose describes discovering he has aphantasia, a condition where one cannot voluntarily visualize mental images. For these individuals, abstract concepts and memories are experienced through feelings and kinesthetics rather than vivid pictures, highlighting vast, often unknown, differences in human cognition.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

Therapist Terry Real Argues "Objective Reality" Has No Place in Relationship Conflicts

Winning an argument by proving a factual point (e.g., "you were technically yelling") is a losing strategy in relationships. Therapist Terry Real's framework suggests subjective perception is what truly matters. Establishing "objective reality" invalidates your partner's experience and derails resolution.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

An Old Antibiotic, D-cycloserine, Can Amplify Transcranial Magnetic Stimulation (TMS) for Anxiety

Tim Ferriss found combining accelerated Transcranial Magnetic Stimulation (TMS) with the antibiotic D-cycloserine (DCS) made a single day of treatment as effective as a full week. DCS, a cognitive enhancer, appears to increase neuroplasticity, making the brain more receptive to stimulation and dramatically reducing treatment time.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

Create Instant Audio Primers on Any Topic by Feeding an AI-Generated Research Guide into Google's NotebookLM

A powerful learning hack: 1) Ask an LLM (like Gemini) for a deep research guide on a topic. 2) Paste the text into Google's NotebookLM. 3) Prompt NotebookLM to "create a five-minute podcast" summarizing the material. This transforms dense information into a quick, digestible audio primer for learning on the go.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

Kevin Rose's '2-2-2 Rule' Offers a Framework for Mindful Alcohol Consumption

After a six-month sobriety period, Kevin Rose adopted the '2-2-2 rule': a maximum of two drinks, never on consecutive days, and on a maximum of two days per week. This structured approach helps re-evaluate one's relationship with alcohol without complete abstinence, focusing on moderation and special occasions.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

DORA Sleep Medications (e.g., Belsomra) May Reduce Alzheimer's Risk by Clearing Brain Plaque

Unlike sedatives, DORA-class sleep aids (Dual Orexin Receptor Antagonists) work by inhibiting wakefulness, creating more natural sleep architecture. Research suggests this may improve the brain's ability to clear beta-amyloid and tau proteins linked to Alzheimer's disease, offering a potential preventative strategy.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

Google's Custom TPU Chips Give It a Full-Stack AI Advantage Over NVIDIA-Reliant Rivals

While competitors like OpenAI must buy GPUs from NVIDIA, Google trains its frontier AI models (like Gemini) on its own custom Tensor Processing Units (TPUs). This vertical integration gives Google a significant, often overlooked, strategic advantage in cost, efficiency, and long-term innovation in the AI race.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago

AI Models Are Improving So Fast That Opinions Formed Three Months Ago Are Already Obsolete

Kevin Rose argues against forming fixed opinions on AI capabilities. The technology leapfrogs every 4-8 weeks, meaning a developer who found AI coding assistants "horrible" three months ago is judging a tool that is now 3-4 times better. One must continuously re-evaluate AI tools to stay current.

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello thumbnail

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show·3 months ago