For B2B re-engagement, a highly effective subject line is "Are you still with [Company Name]?". This personalizes the email at scale by dynamically inserting the contact's employer. It grabs attention and prompts an open to confirm or update their status, successfully re-engaging them with your content or offers.

From Nov 20th to Dec 20th, sending a personal letter-style email from a founder or executive to unengaged contacts can increase open rates by 40%. The key is changing the "from name" to a person, not the brand, and using a subject line that acknowledges their absence. This strategy works for both B2B and B2C brands.

Generic "we miss you" campaigns fail. Instead of a simple message, leverage integrated data to personalize outreach based on an HCP's past behavior. This "we miss you, and we know you" approach has yielded click-through rates exceeding 40% by offering highly relevant content suggestions.

In an era of mass automation, customers notice and value actions they know can't be easily scaled. Instead of another automated email, send a personal video via text, a handwritten note, or "lumpy mail." These high-effort signals cut through the noise and show genuine appreciation.

Outbound AI tools fail without dedicated human oversight. Qualified found success by having a person manage the AI agent daily, ensuring its personalized emails are better than a human's. The secret is treating the AI as a tool to be managed, not an autonomous replacement.

Prompting subscribers with simple, non-work-related questions (e.g., "What's your favorite holiday cookie?") encourages replies. This builds a conversational relationship, improves engagement signals, and positively impacts email deliverability and open rates.

Sending all your automated emails at a predictable time, like 9 AM, trains your audience to ignore them, turning them into "wallpaper." To break this pattern and make automations feel less robotic, vary the send times significantly, even using unconventional hours like 8 PM.

For subscribers who don't open an email, a simple and effective tactic is to resend the exact same content. The only change is tweaking the subject line and pre-header to capture their attention. Since they never saw the original content, it's still new to them and requires minimal effort to redeploy.

Avoid list-cleaning automations with a small subscriber base (e.g., under 1,000). Instead of deleting inactive subscribers, personally email them to ask what they're struggling with. This approach turns a technical cleanup task into a valuable user research and re-engagement opportunity.