When a large company acquires a startup, the natural tendency is to impose its standardized processes. Successful integration requires a balance: knowing which systems to standardize for leverage while allowing the acquired team to maintain its freewheeling, startup-style execution.

Amphenol runs as a federation of autonomous business units. This structure is key to its M&A success, as acquired companies retain their brand, culture, and customer intimacy. Sellers prefer Amphenol because they know their business won't be suffocated by a monolithic corporate hierarchy.

A counterintuitive benefit of being acquired by a larger company is improved internal team cohesion. The sudden influx of new partnerships and opportunities from the acquiring entity can compel the smaller team to work more closely together, fostering stronger alignment and mutual support.

Cisco rejects a one-size-fits-all integration timeline. It rapidly integrates corporate functions like HR, finance, and legal for control and compliance. However, it takes a more measured, "surgical" approach with core value drivers like engineering and sales to protect the acquired company's unique strengths.

Successful large-scale acquirers remain nimble, flexing their own processes to suit the acquired company rather than force-fitting it into a rigid corporate structure. This preserves the culture and talent that made the company valuable, preventing value destruction and keeping the new team engaged.

When integrating acquired biotechs, Merck prioritizes retaining key talent and preserving ongoing science. The strategy involves immediate face-to-face engagement to reduce anxiety, followed by a pragmatic assessment of which processes must be standardized versus which can remain to avoid disrupting critical trials, a practice they call avoiding 'mercification'.

The "conquering hero" approach of forcing an acquired company to adopt your processes is the cardinal sin of M&A. Omar Tawakol's experience at Oracle showed that protecting an acquisition's unique workflows and incentives leads to growth, while rapid, forced integration destroys value.

A one-size-fits-all integration can destroy the culture that made an acquisition valuable. When State Street acquired software firm CRD, it intentionally broke from its standard process, allowing CRD to keep its brand identity, facilities, and even email domain to preserve its creative culture and retain key talent.

For certain acquisitions like Poker, IFS deliberately avoids full integration to retain the target's agile, entrepreneurial culture. Instead, they use product connectors and provide access to parent company resources, allowing the startup to maintain its dynamism while leveraging scale.