Brain imaging suggests people with ADHD may have a reward pathway that is less activated by stimuli and contains fewer dopamine receptors at baseline. This inherent "reward deficit" could create a state of craving even before exposure to addictive substances, increasing vulnerability.

Neuroscience shows pleasure and pain are co-located in the brain and work like a seesaw. When we experience pleasure, the brain immediately compensates by tilting towards pain to restore balance. This neurological 'come down' is why constant pleasure-seeking eventually leads to a state of chronic pain and craving.

Many people use substances to treat anxiety or depression, not realizing the substance itself causes a dopamine deficit that mimics those conditions. Abstaining for four weeks allows the brain to reset its reward pathways and restore natural dopamine production, often resolving the symptoms entirely.

Dopamine is often misunderstood as a 'pleasure molecule.' Its more crucial role is in motivation—the drive to seek a reward. Experiments show rats without dopamine receptors enjoy food but won't move to get it, starving to death. This seeking behavior is often triggered by the brain's craving to escape a dopamine deficit state.

To break a bad habit, abstain from your "drug of choice" for at least four weeks. This is the average time needed to escape acute withdrawal (which peaks in the first 14 days) and allow the brain's neuroplasticity to restore its ability to enjoy modest, natural rewards again.

Alcohol temporarily reduces anxiety by boosting the neurotransmitter GABA. However, the brain overcompensates by converting GABA into glutamate, an excitatory neurotransmitter. This rebound effect leaves you more anxious than before, creating a self-perpetuating cycle of self-medication.

An animal study shows a rat, when painfully shocked, will immediately try to get cocaine again even after the habit was extinguished. This models how humans under stress revert to high-dopamine rewards because the brain has encoded this as the fastest way out of any painful state.

Addiction isn't defined by the pursuit of pleasure. It's the point at which a behavior, which may have started for rational reasons, hijacks the brain’s reward pathway and becomes compulsive. The defining characteristic is the inability to stop even when the behavior no longer provides pleasure and begins causing negative consequences.

Constantly bombarding our reward pathways causes the brain to permanently weigh down the 'pain' side of its pleasure-pain balance. This alters our baseline mood, or 'hedonic set point,' meaning we eventually need our substance or behavior not to get high, but simply to escape a state of withdrawal and feel normal.