During periods of intense market euphoria, investors with experience of past downturns are at a disadvantage. Their knowledge of how bubbles burst makes them cautious, causing them to underperform those who have only seen markets rebound, reinforcing a dangerous cycle of overconfidence.

The most imprudent lending decisions occur during economic booms. Widespread optimism, complacency, and fear of missing out cause investors to lower their standards and overlook risks, sowing the seeds for future failures that are only revealed in a downturn.

Emilie Choi explains that market downturns are beneficial because they drive out short-term "mercenaries," allowing dedicated builders to thrive. Her promotion came from proving she could operate effectively during a downturn, rewarding her resilience when others fled.

Market stability is an evolutionary process where each crisis acts as a learning event. The 2008 crash taught policymakers how to respond with tools like credit facilities, enabling a much faster, more effective response to the COVID-19 shock. Crises are not just failures but necessary reps that improve systemic resilience.

The best time to launch a company is at the bottom of a recession. Key inputs like talent and real estate are cheap, which enforces extreme financial discipline. If a business can survive this environment, it emerges as a lean, resilient "fighting machine" perfectly positioned to capture upside when the market recovers.

Investor Peter Lynch's advice highlights that trying to anticipate downturns often leads to missed gains, which can be more costly than the losses from the downturns themselves. The best strategy is often to stay invested rather than waiting on the sidelines for a crash that is impossible to predict.

During a stock downturn, Rhythm's CFO showed his team historical charts of successful biotech firms like Vertex and Regeneron that also endured long periods of low valuation. This tangible proof of long-term potential in a volatile industry served as a powerful tool to maintain employee morale and focus.

Judging investment skill requires observing performance through both bull and bear markets. A fixed period, like 5 or 10 years, can be misleading if it only captures one type of environment, often rewarding mere risk tolerance rather than genuine ability.

In a paradigm shift like AI, an experienced hire's knowledge can become obsolete. It's often better to hire a hungry junior employee. Their lack of preconceived notions, combined with a high learning velocity powered by AI tools, allows them to surpass seasoned professionals who must unlearn outdated workflows.