Bryan Johnson suggests focusing on a single metric: pre-sleep resting heart rate. Lowering it through specific habits (like eating 4 hours before bed) improves sleep quality, which in turn boosts your prefrontal cortex, enhancing willpower and alleviating mental health issues.

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Improving sleep quality is one of the cheapest and highest-leverage investments you can make. Simple, one-time purchases like blackout curtains and earplugs can dramatically improve decision-making, energy, and recovery, yielding permanent benefits for minimal cost.

Ferriss notes significant physiological changes while in ketosis, including needing 2-3 fewer hours of sleep and at least doubling his breath-hold time. He also experiences a dramatic reduction in ruminative thoughts, improving mental clarity and sleep onset.

To overcome negative mental states like depression, focus on physical action rather than cognitive wrestling. Activities like intense exercise, clean eating, or even simple biological hacks like side-to-side eye movement directly alter your neurochemistry, offering a more effective path to change than thought alone.

Functions we consider involuntary, like heart rate, immune response, and body temperature, can be consciously influenced. By controlling the breath, we can directly tap into the autonomic nervous system, enabling us to shift between a 'fight or flight' state and a 'rest and digest' state to manage stress and improve health.

Scheduled thinking time acts as a mental clearinghouse, preventing unprocessed thoughts from racing at night. This practice improves sleep quality and reduces overall stress and anxiety, leading to calmer, more considered decision-making instead of knee-jerk reactions.

True rest requires a mental break, not just a physical one. Use a technique called "noting" to detach from stress-inducing thought loops. When you catch your mind spiraling—even while physically resting—simply label the activity: "worrying," "planning," or "comparing." This act of observation creates distance, helping you step away from the story and return to the present moment.

Instead of building many habits at once, focus on one or two 'upstream' ones that cause a cascade of positive effects. For example, exercising regularly often leads to better sleep, improved focus, and healthier eating habits without directly trying to change them.

Instead of asking, "Have I worked enough to deserve rest?", ask, "Have I rested enough to do my best work?" This shift reframes rest from a reward you must earn into a necessary input for quality, compassion, and higher-level thinking. When in a fight-or-flight state, you lack access to the brain regions required for your most meaningful work.

Biohacker Bryan Johnson directly challenges the "grind culture" belief that founders must sacrifice health and sleep for success. He argues this is a false narrative, stating that prioritizing high-quality sleep will make an individual a more effective leader, parent, and partner.

Regardless of the primary goal—be it focus, anxiety, or performance—99% of neurofeedback clients report improved sleep as the first noticeable change. This typically occurs within the first 5 to 15 sessions, signaling that the brain is beginning to self-regulate more effectively.