Gladwell argues that when systems like vaccination are highly effective, people feel safe enough to entertain crackpot theories. The success of these systems removes the immediate, tangible stakes, creating a 'moral hazard' that permits intellectual laziness and fantastical thinking.

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The human brain is wired to fear scarcity and solve problems. When technology and capitalism fulfill most basic needs, this problem-solving instinct doesn't disappear. It latches onto more abstract, often social or political, issues, fueling neurosis and creating a population that externalizes its anxieties onto the world.

The tendency to blame a single entity for disparate negative events isn't about logic but about satisfying a deep psychological need for order and control. This "derangement syndrome" provides a simple, pre-made narrative that assigns blame and creates a sense of understanding, regardless of evidence.

The appeal of complex conspiracies isn't just about information; it's psychological. Believing you are at the center of a vast plot makes life more exciting and meaningful. The realization that one is not important can lead to "secondary depression," making the conspiracy narrative preferable to reality.

The erosion of trusted, centralized news sources by social media creates an information vacuum. This forces people into a state of 'conspiracy brain,' where they either distrust all information or create flawed connections between unverified data points.

Effective vaccines eradicate the visible horror of diseases. By eliminating the pain and tragic outcomes from public memory, vaccines work against their own acceptance. People cannot fear what they have never seen, leading to complacency and vaccine hesitancy because the terrifying counterfactual is unimaginable.

Humans crave control. When faced with uncertainty, the brain compensates by creating narratives and seeing patterns where none exist. This explains why a conspiracy theory about a planned event can feel more comforting than a random, chaotic one—the former offers an illusion of understandable order.

The human brain resists ambiguity and seeks closure. When a significant, factual event occurs but is followed by a lack of official information (often for legitimate investigative reasons), this creates an "open loop." People will naturally invent narratives to fill that void, giving rise to conspiracy theories.

Societal fears, or "moral panics," are cyclical. While the targets change (from witchcraft to 5G wireless), the underlying tactics of exploiting fears around child safety and innocence remain consistent throughout history, repeating the same patterns.

Unprecedented global prosperity creates a vacuum of real adversity, leading people to invent anxieties and fixate on trivial problems. Lacking the perspective from genuine struggle, many complain about first-world issues while ignoring their immense privilege, leading to a state where things are 'so good, it's bad.'

Applying Hanlon's Razor ("Don't attribute to malice what is adequately explained by incompetence"), it's more probable that a political figure was killed due to security failures than a complex, flawless conspiracy by a foreign state. Incompetence is statistically more common than a perfectly executed secret plot.