When evaluating AI startups, don't just consider the current product landscape. Instead, visualize the future state of giants like OpenAI as multi-trillion dollar companies. Their "sphere of influence" will be vast. The best opportunities are "second-order" companies operating in niches these giants are unlikely to touch.

Instead of selling software to traditional industries, a more defensible approach is to build vertically integrated companies. This involves acquiring or starting a business in a non-sexy industry (e.g., a law firm, hospital) and rebuilding its entire operational stack with AI at its core, something a pure software vendor cannot do.

The "AI wrapper" concern is mitigated by a multi-model strategy. A startup can integrate the best models from various providers for different tasks, creating a superior product. A platform like OpenAI is incentivized to only use its own models, creating a durable advantage for the startup.

For specialized, high-stakes tasks like insurance underwriting, enterprises will favor smaller, on-prem models fine-tuned on proprietary data. These models can be faster, more accurate, and more secure than general-purpose frontier models, creating a lasting market for custom AI solutions.

Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.

Startups are becoming wary of building on OpenAI's platform due to the significant risk of OpenAI launching competing applications (e.g., Sora for video), rendering their products obsolete. This "platform risk" is pushing developers toward neutral providers like Anthropic or open-source models to protect their businesses.

While AI labs could build competing enterprise apps, the required effort (sales teams, customizations) is massive. For a multi-billion dollar company, the resulting revenue is a rounding error, making it an illogical distraction from their core model-building business.

Anthropic is making its models available on AWS, Azure, and Google Cloud. This multi-cloud approach is a deliberate business strategy to position itself as a neutral infrastructure provider. Unlike competitors who might build competing apps, this signals to customers that Anthropic aims to be a partner, not a competitor.

Don't underestimate the size of AI opportunities. Verticals like "AI for code" or "AI for legal" are not niche markets that will be dominated by a few players. They are entire new industries that will support dozens of large, successful companies, much like the broader software industry.