Instead of competing with OpenAI's mass-market ChatGPT, Anthropic focuses on the enterprise market. By prioritizing safety, reliability, and governance, it targets regulated industries like finance, legal, and healthcare, creating a defensible B2B niche as the "enterprise safety and reliability leader."

When evaluating AI startups, don't just consider the current product landscape. Instead, visualize the future state of giants like OpenAI as multi-trillion dollar companies. Their "sphere of influence" will be vast. The best opportunities are "second-order" companies operating in niches these giants are unlikely to touch.

Unlike cloud or mobile, which incumbents initially ignored, AI adoption is consensus. Startups can't rely on incumbents being slow. The new 'white space' for disruption exists in niche markets large companies still deem too small to enter.

Instead of selling software to traditional industries, a more defensible approach is to build vertically integrated companies. This involves acquiring or starting a business in a non-sexy industry (e.g., a law firm, hospital) and rebuilding its entire operational stack with AI at its core, something a pure software vendor cannot do.

The "AI wrapper" concern is mitigated by a multi-model strategy. A startup can integrate the best models from various providers for different tasks, creating a superior product. A platform like OpenAI is incentivized to only use its own models, creating a durable advantage for the startup.

Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.

Instead of building AI models, a company can create immense value by being 'AI adjacent'. The strategy is to focus on enabling good AI by solving the foundational 'garbage in, garbage out' problem. Providing high-quality, complete, and well-understood data is a critical and defensible niche in the AI value chain.

Startups are becoming wary of building on OpenAI's platform due to the significant risk of OpenAI launching competing applications (e.g., Sora for video), rendering their products obsolete. This "platform risk" is pushing developers toward neutral providers like Anthropic or open-source models to protect their businesses.

The choice between open and closed-source AI is not just technical but strategic. For startups, feeding proprietary data to a closed-source provider like OpenAI, which competes across many verticals, creates long-term risk. Open-source models offer "strategic autonomy" and prevent dependency on a potential future rival.