OpenAI embraces the 'platform paradox' by selling API access to startups that compete directly with its own apps like ChatGPT. The strategy is to foster a broad ecosystem, believing that enabling competitors is necessary to avoid losing the platform race entirely.

When evaluating AI startups, don't just consider the current product landscape. Instead, visualize the future state of giants like OpenAI as multi-trillion dollar companies. Their "sphere of influence" will be vast. The best opportunities are "second-order" companies operating in niches these giants are unlikely to touch.

Unlike cloud or mobile, which incumbents initially ignored, AI adoption is consensus. Startups can't rely on incumbents being slow. The new 'white space' for disruption exists in niche markets large companies still deem too small to enter.

Established SaaS firms avoid AI-native products because they operate at lower gross margins (e.g., 40%) compared to traditional software (80%+). This parallels brick-and-mortar retail's fatal hesitation with e-commerce, creating an opportunity for AI-native startups to capture the market by embracing different unit economics.

Fal strategically chose not to compete in LLM inference against giants like OpenAI and Google. Instead, they focused on the "net new market" of generative media (images, video), allowing them to become a leader in a fast-growing, less contested space.

Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.

Google authored the seminal 'Transformers' AI paper but failed to capitalize on it, allowing outsiders to build the next wave of AI. This shows how incumbents can be so 'lost in the sauce' of their current paradigm that they don't notice when their own research creates a fundamental shift.

Ken Griffin warns startups against direct, head-on competition with industry giants, stating, "you're going to lose." To succeed, you must find an asymmetrical advantage—operating "under the radar" or solving niche problems incumbents ignore. Citadel initially did this by hiring unconventional quantitative talent.

Conventional venture capital wisdom of 'winner-take-all' may not apply to AI applications. The market is expanding so rapidly that it can sustain multiple, fast-growing, highly valuable companies, each capturing a significant niche. For VCs, this means huge returns don't necessarily require backing a monopoly.