Instead of charging doctors for its valuable productivity tools, Doximity offers them for free to maximize user engagement. This creates a highly concentrated, valuable audience of physicians, which is then monetized through targeted advertising from pharmaceutical companies, its primary revenue source.

Horizontal SaaS companies fracture their customer knowledge across diverse industries, forcing generic messaging. Vertical SaaS companies build compounding knowledge with each customer within a niche. This leads to deeper insights, stronger competitive secrets, and more effective, specific messaging over time.

For specialized, high-stakes tasks like insurance underwriting, enterprises will favor smaller, on-prem models fine-tuned on proprietary data. These models can be faster, more accurate, and more secure than general-purpose frontier models, creating a lasting market for custom AI solutions.

Higgsfield initially saw high adoption for viral, consumer-facing AI features but pivoted. They realized foundation model players like OpenAI will dominate and subsidize these markets. The defensible startup strategy is to ignore consumer virality and solve specific, monetizable B2B workflow problems instead.

Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.

The partnership where OpenAI becomes an equity holder in Thrive Holdings suggests a new go-to-market model. Instead of tech firms pushing general AI 'outside-in,' this 'inside-out' approach embeds AI development within established industry operators to build, test, and improve domain-specific models with real-world feedback loops.

An app bundling various LLMs into one interface is making $300k/month. Replicate this success by targeting a specific professional niche like lawyers or teachers. Stitch together models and workflows to become the default AI assistant for that vertical.

Most successful SaaS companies weren't built on new core tech, but by packaging existing tech (like databases or CRMs) into solutions for specific industries. AI is no different. The opportunity lies in unbundling a general tool like ChatGPT and rebundling its capabilities into vertical-specific products.

Successful vertical AI applications serve as a critical intermediary between powerful foundation models and specific industries like healthcare or legal. Their core value lies in being a "translation and transformation layer," adapting generic AI capabilities to solve nuanced, industry-specific problems for large enterprises.