Instead of competing with OpenAI's mass-market ChatGPT, Anthropic focuses on the enterprise market. By prioritizing safety, reliability, and governance, it targets regulated industries like finance, legal, and healthcare, creating a defensible B2B niche as the "enterprise safety and reliability leader."

When evaluating AI startups, don't just consider the current product landscape. Instead, visualize the future state of giants like OpenAI as multi-trillion dollar companies. Their "sphere of influence" will be vast. The best opportunities are "second-order" companies operating in niches these giants are unlikely to touch.

Unlike cloud or mobile, which incumbents initially ignored, AI adoption is consensus. Startups can't rely on incumbents being slow. The new 'white space' for disruption exists in niche markets large companies still deem too small to enter.

Higgsfield initially saw high adoption for viral, consumer-facing AI features but pivoted. They realized foundation model players like OpenAI will dominate and subsidize these markets. The defensible startup strategy is to ignore consumer virality and solve specific, monetizable B2B workflow problems instead.

Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.

Despite the hype, YC's focus isn't just on pure AI startups. The accelerator is backing a diverse portfolio of companies in healthcare, finance, and deep tech, using AI as a disruptive tool to rewrite the rules of these traditional, 'dusty' industries, much like the internet did.

Most successful SaaS companies weren't built on new core tech, but by packaging existing tech (like databases or CRMs) into solutions for specific industries. AI is no different. The opportunity lies in unbundling a general tool like ChatGPT and rebundling its capabilities into vertical-specific products.

Successful vertical AI applications serve as a critical intermediary between powerful foundation models and specific industries like healthcare or legal. Their core value lies in being a "translation and transformation layer," adapting generic AI capabilities to solve nuanced, industry-specific problems for large enterprises.

YC Partner Harsh Taggar notes a strategic shift where new AI companies are not just selling software to incumbents (e.g., an AI tool for insurance). Instead, they are building "AI-native full stack" businesses that operate as the incumbent themselves (e.g., an AI-powered insurance brokerage).