Contrary to advisors who predicted EHRs would quickly fix healthcare data, Matt Holt invested in HealthPort, believing the system's deep brokenness provided a 15-20 year runway. The insight is that intractable, systemic fragmentation creates durable opportunities for foundational infrastructure players.

Related Insights

The founders initially feared their data collection hardware would be easily copied. However, they discovered the true challenge and defensible moat lay in scaling the full-stack system—integrating hardware iterations, data pipelines, and training loops. The unexpected difficulty of this process created a powerful competitive advantage.

History shows pioneers who fund massive infrastructure shifts, like railroads or the early internet, frequently lose their investment. The real profits are captured later by companies that build services on top of the now-established, de-risked platform.

A company can build a significant competitive advantage in healthcare by deliberately *not* touching or seeing Protected Health Information (PHI). Focusing exclusively on metadata reduces regulatory overhead and security risks, allowing the business to solve the critical problem of data orchestration and intelligence, a layer often neglected by data aggregators.

An early, painful experience as acting CFO for a surgery center that struggled to get paid—a deal nicknamed "Death by a Thousand Cuts"—directly shaped the firm's successful healthcare strategy. This scar tissue led to a vow to avoid direct care provision and focus exclusively on less glamorous but more defensible IT and data infrastructure.

Doximity integrates multiple workflow tools like telehealth and e-signatures. While specialized competitors might offer better individual products, Doximity wins by providing a convenient, all-in-one platform that doctors are already engaged with daily, creating a powerful defensive moat.

Unlike SaaS startups focused on finding product-market fit (market risk), deep tech ventures tackle immense technical challenges. If they succeed, they enter massive, pre-existing trillion-dollar markets like energy or shipping where demand is virtually guaranteed, eliminating market risk entirely.

A competitive moat can be built by moving beyond simple service delivery (e.g., shipping medicine) to a closed-loop system. This involves diagnostics to establish a baseline, personalized treatment plans based on results, and ongoing re-testing to demonstrate improvement, creating a sticky user journey.

Drawing from Verkada's decision to build its own hardware, the strategy is to intentionally tackle difficult, foundational challenges early on. While this requires more upfront investment and delays initial traction, it creates an immense competitive barrier that latecomers will struggle to overcome.

The excitement around AI capabilities often masks the real hurdle to enterprise adoption: infrastructure. Success is not determined by the model's sophistication, but by first solving foundational problems of security, cost control, and data integration. This requires a shift from an application-centric to an infrastructure-first mindset.

The core issue preventing a patient-centric system is not a lack of technological capability but a fundamental misalignment of incentives and a deep-seated lack of trust between payers and providers. Until the data exists to change incentives, technological solutions will have limited impact.