An 85-year Harvard study on adult life revealed that the strongest predictor of long-term health and happiness isn't wealth, fame, or power, but the quality of close relationships. Having even one person to count on is the key protective factor for a good life.

Hope is the belief that a positive outcome is possible, while optimism is the expectation that it is probable. Maintaining hope provides motivation to act, but avoiding optimism prevents complacency and allows for contingency planning for negative outcomes. This distinction is crucial for navigating volatile situations.

Seemingly harmless jokes and dismissive attitudes about aging are not benign. The World Health Organization found that older adults with negative self-perceptions about their own aging live, on average, 7.5 years less than those with positive views, making the psychological impact of ageism a significant public health hazard.

Counteract the human tendency to focus on negativity by consciously treating positive events as abundant and interconnected ("plural") while framing negative events as isolated incidents ("singular"). This mental model helps block negative prophecies from taking hold.

People facing death find joy not because their suffering is gone, but because they consciously look for and acknowledge positive moments. A dying client used a simple tally device, a "joy counter," to track every small good thing, which retrained his focus on what was still present and good in his life.

Drawing inspiration from Antarctic explorer Ernest Shackleton, true optimism isn't a passive belief that things will work out. It's an active, courageous choice. In dire situations, a leader's decision to be optimistic is a strategic tool essential for survival and success.

A 7-year study of healthy individuals over 85 found minimal genetic differences from their less healthy counterparts. The key to their extreme healthspan appears to be a robust immune system, which is significantly shaped by lifestyle choices, challenging the common narrative about being born with "good genes."

A physician with decades of experience observes that a patient's innate belief in their own ability to heal is a critical factor in recovery. Those who do not believe they can get better almost never do, as the stress of negative thinking actively fights their own physiology.

The common aversion to living to 120 stems from assuming extra years will be spent in poor health. The goal of longevity science is to extend *healthspan*—the period of healthy, mobile life—which reframes the debate from merely adding years to adding high-quality life.