McInerney's success comes from profiling founders, not just markets. He seeks deep domain expertise combined with a unique, often unconventional, perspective, believing this combination is key to building disruptive companies.

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The firm's thesis focuses on a rare founder type: a technical expert who also deeply understands how new technologies shift human behavior. This avoids the common pitfall of building technology in search of a problem, leading to products with innate market pull.

The most successful venture investors share two key traits: they originate investments from a first-principles or contrarian standpoint, and they possess the conviction to concentrate significant capital into their winning portfolio companies as they emerge.

The ideal founder archetype starts with deep technical expertise and product sense. They then develop exceptional business and commercial acumen over time, a rarer and more powerful combination than a non-technical founder learning the product.

Redpoint Ventures' Erica Brescia describes a shift in their investment thesis for the AI era. They are now more likely to back young, "high-velocity" founders who "run through walls to win" over those with traditional domain expertise. Sheer speed, storytelling, and determination are becoming more critical selection criteria.

Sequoia's founder taught that the best investments are in individuals who are both exceptional and "not so easy to get along with." These founders challenge convention and refuse to accept the world as it is, a trait that makes them unconventional but also uniquely capable of building category-defining companies.

While domain experts are great at creating incremental improvements, true exponential disruption often comes from founders outside an industry. Their fresh perspective allows them to challenge core assumptions and apply learnings from other fields.

To identify non-consensus ideas, analyze the founder's motivation. A founder with a deep, personal reason for starting their company is more likely on a unique path. Conversely, founders who "whiteboarded" their way to an idea are often chasing mimetic, competitive trends.

A truly exceptional founder is a talent magnet who will relentlessly iterate until they find a winning model. Rejecting a partnership based on a weak initial idea is a mistake; the founder's talent is the real asset. They will likely pivot to a much bigger opportunity.

When evaluating revolutionary ideas, traditional Total Addressable Market (TAM) analysis is useless. VCs should instead bet on founders with a "world-bending vision" capable of inducing a new market, not just capturing an existing one. Have the humility to admit you can't predict market size and instead back the visionary founder.

DFJ Growth Partner Barry Shuler details their strategy of avoiding herd investments by focusing on 'life tech'—the intersection of life sciences and technology. This contrarian approach allows them to back brilliant but lesser-known visionaries in emerging fields like population genomics, where they see immense potential.