Once you become proficient at a mental exercise, its benefit for neuroplasticity diminishes. To keep the brain changing and adapting, you must continually seek new activities that are challenging and unfamiliar, rather than sticking with what you're already good at.

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To rediscover the curiosity needed for work, practice it in low-stakes daily life. Take a different route to work, order a coffee you'd never choose, or read a different genre of book. Consciously observing how these novel experiences feel primes your brain to question assumptions and see new possibilities in your professional environment.

Mastery of a skill isn't about more brain activity, but more efficient activity. Experts transfer tasks from conscious effort ("software") to automated neural circuits ("hardware"), consuming fewer cognitive resources than a novice who is actively problem-solving.

A long-term study found many nuns had brains full of Alzheimer's plaques post-mortem, yet displayed no cognitive decline in life. Their constant social responsibilities and interactions acted as a continuous mental challenge, building new neural pathways that bypassed the damaged areas.

Actively studying new information daily, as if preparing for an exam, builds profound mental and physical resilience. This "brain building" uses new nerve cells that would otherwise become toxic waste. The act of deep thinking strengthens the brain, calms the mind, and enhances your ability to handle stress.

Dr. Levin recommends that scientists learn multiple, conceptually different programming languages not for the coding skill, but for the mental plasticity it builds. Each language offers a new worldview, training the brain to rapidly adopt different conceptual frameworks—a crucial skill for scientific innovation.

The human brain defaults to an energy-saving 'autopilot' mode for predictable routines, like a daily commute. This causes you to be mentally absent and miss large portions of your life. Introducing novelty and unpredictable experiences is crucial because it forces your brain to disengage autopilot and become present and focused.

While repetition is crucial for skill mastery, the brain eventually stops recording familiar experiences to conserve energy. This neurological efficiency causes our perception of time to speed up as we age. To counteract this, one must intentionally introduce new challenges to keep the brain actively creating new memories.

Training methods leverage the brain's predictive nature. Repetitive practice makes the brain efficient at predicting movements, leading to mastery and lower energy use ('muscle memory'). In contrast, unpredictable training creates constant prediction errors, forcing adaptation and burning more calories, which drives growth and resilience.

Beyond the mid-20s, the primary mechanism for rewiring the brain (neuroplasticity) is making a prediction and realizing it was wrong. This makes mistakes a biological necessity for growth and becoming more capable. It reframes errors not just as learning opportunities, but as the central, physiological catalyst for adult learning and improvement.

After age 25, the brain stops changing from passive experience. To learn new skills or unlearn patterns, one must be highly alert and focused. This triggers a release of neuromodulators like dopamine and epinephrine, signaling the brain to physically reconfigure its connections during subsequent rest.