Ferriss points to the emerging field of metabolic psychiatry, where dietary intervention is used for severe mental illness. He cites cases where schizophrenia patients, after years of failed medications, get off all prescriptions by adopting a ketogenic diet. This approach stabilizes the brain by providing ketones as a clean energy source.

To overcome negative mental states like depression, focus on physical action rather than cognitive wrestling. Activities like intense exercise, clean eating, or even simple biological hacks like side-to-side eye movement directly alter your neurochemistry, offering a more effective path to change than thought alone.

By preventing the compulsive response (e.g., not checking), Exposure and Response Prevention (ERP) forces the individual to sit with their anxiety. They learn firsthand that the anxiety will eventually fade on its own, a process called extinction decay, which breaks the reinforcement cycle.

To break a bad habit, abstain from your "drug of choice" for at least four weeks. This is the average time needed to escape acute withdrawal (which peaks in the first 14 days) and allow the brain's neuroplasticity to restore its ability to enjoy modest, natural rewards again.

Ferriss highlights Accelerated Transcranial Magnetic Stimulation (TMS), a non-invasive protocol involving 10 sessions a day for five days. He describes it as a powerful, safe treatment for severe conditions like treatment-resistant depression. For him, it resulted in four to five months of zero anxiety, an effect he calls "incomprehensible."

Evolutionary modeling shows that taking antibiotics beyond symptom resolution can be counterproductive. It needlessly kills off susceptible bacteria, creating a perfect environment for resistant strains to flourish. The optimal strategy is often to stop once the immune system can handle the rest, contrary to decades of medical advice.

Specific auditory patterns can directly impact brain function. Research shows that 40 Hz binaural beats can increase striatal dopamine, a neurotransmitter crucial for motivation and focus. This leads to improved memory, faster reaction times, and better verbal recall. Listening for 30 minutes prior to a work session can prime your brain for high performance.

Tim Ferriss found combining accelerated Transcranial Magnetic Stimulation (TMS) with the antibiotic D-cycloserine (DCS) made a single day of treatment as effective as a full week. DCS, a cognitive enhancer, appears to increase neuroplasticity, making the brain more receptive to stimulation and dramatically reducing treatment time.

A therapy called IRT treats nightmares by leveraging memory reconsolidation. Patients actively recall a traumatic dream, rewrite its narrative and outcome while awake, and then resave the updated, less threatening version during their next sleep cycle, gradually diminishing its power.