An AI-native VC firm operates like a product company, developing in-house intelligence platforms to amplify human judgment. This is a fundamental shift from simply using tools like Affinity or Harmonics, creating a defensible operational advantage in sourcing, screening, and winning deals.

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Answering "Why are you different?" requires deep thinking that connects strategy to operations. Han Shin of iFly explains that true differentiation is a cohesive system—his fund's thesis-driven research, concentrated portfolio, and large check sizes are all interconnected, enabling the deep, hands-on support that defines his value proposition.

Traditional VC reliance on "differentiated networks" is obsolete as data sources and professional networks are now commodities. To compete, modern VCs must replace this outdated advantage with proprietary intelligence platforms that algorithmically source deals and identify the right signals for where to focus time.

Incumbent companies are slowed by the need to retrofit AI into existing processes and tribal knowledge. AI-native startups, however, can build their entire operational model around agent-based, prompt-driven workflows from day one, creating a structural advantage that is difficult for larger companies to copy.

The key for enterprises isn't integrating general AI like ChatGPT but creating "proprietary intelligence." This involves fine-tuning smaller, custom models on their unique internal data and workflows, creating a competitive moat that off-the-shelf solutions cannot replicate.

Instead of only investing in tech, Sequoia builds it. The firm employs as many developers as investors to create proprietary tools. This includes an AI system that summarizes business plans, analyzes team quality, and maps competitive dynamics, giving partners an immediate, data-rich overview of opportunities.

WCM avoids generic AI use cases. Instead, they've built a "research partner" AI model specifically tuned to codify and diagnose their core concepts of "moat trajectory" and "culture." This allows them to amplify their unique edge by systematically flagging changes across a vast universe of data, rather than just automating simple tasks.

The true enterprise value of AI lies not in consuming third-party models, but in building internal capabilities to diffuse intelligence throughout the organization. This means creating proprietary "AI factories" rather than just using external tools and admiring others' success.

Incumbents face the innovator's dilemma; they can't afford to scrap existing infrastructure for AI. Startups can build "AI-native" from a clean sheet, creating a fundamental advantage that legacy players can't replicate by just bolting on features.

A key competitive advantage wasn't just the user network, but the sophisticated internal tools built for the operations team. Investing early in a flexible, 'drag-and-drop' system for creating complex AI training tasks allowed them to pivot quickly and meet diverse client needs, a capability competitors lacked.

YC Partner Harsh Taggar notes a strategic shift where new AI companies are not just selling software to incumbents (e.g., an AI tool for insurance). Instead, they are building "AI-native full stack" businesses that operate as the incumbent themselves (e.g., an AI-powered insurance brokerage).