Contrary to the post-COVID trend of tech decentralization, the intense talent and capital requirements of AI have caused a rapid re-centralization. Silicon Valley has 'snapped back' into a hyper-concentrated hub, with nearly all significant Western AI companies originating within a small geographic radius.

With industry dominating large-scale compute, academia's function is no longer to train the biggest models. Instead, its value lies in pursuing unconventional, high-risk research in areas like new algorithms, architectures, and theoretical underpinnings that commercial labs, focused on scaling, might overlook.

Instead of selling software to traditional industries, a more defensible approach is to build vertically integrated companies. This involves acquiring or starting a business in a non-sexy industry (e.g., a law firm, hospital) and rebuilding its entire operational stack with AI at its core, something a pure software vendor cannot do.

With industry dominating large-scale model training, academia’s comparative advantage has shifted. Its focus should be on exploring high-risk, unconventional concepts like new algorithms and hardware-aligned architectures that commercial labs, focused on near-term ROI, cannot prioritize.

The democratization of technology via AI shifts the entrepreneurial goalpost. Instead of focusing on creating a handful of billion-dollar "unicorns," the more impactful ambition is to empower millions of people to each build a million-dollar "donkey corn" business, truly broadening economic opportunity.

With industry dominating large-scale model training, academic labs can no longer compete on compute. Their new strategic advantage lies in pursuing unconventional, high-risk ideas, new algorithms, and theoretical underpinnings that large commercial labs might overlook.

For years, access to compute was the primary bottleneck in AI development. Now, as public web data is largely exhausted, the limiting factor is access to high-quality, proprietary data from enterprises and human experts. This shifts the focus from building massive infrastructure to forming data partnerships and expertise.

CZI's Biohub model hinges on a simple principle: physically seating biologists and engineers from different institutions (Stanford, UCSF, Berkeley) together. This direct proximity fosters collaboration and creates hybrid experts, overcoming the institutional silos often reinforced by traditional grant-based funding.

Instead of relying on hyped benchmarks, the truest measure of the AI industry's progress is the physical build-out of data centers. Tracking permits, power consumption, and satellite imagery reveals the concrete, multi-billion dollar bets being placed, offering a grounded view that challenges both extreme skeptics and believers.