Instead of building generic chatbot wrappers, entrepreneurs should target high-value niches by building tools on top of specialized AI models. For example, creating an 'AlphaFold wrapper' could create a multi-billion dollar company by serving the specific workflow needs of pharmaceutical companies and research labs.
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The AI industry is hitting data limits for training massive, general-purpose models. The next wave of progress will likely come from creating highly specialized models for specific domains, similar to DeepMind's AlphaFold, which can achieve superhuman performance on narrow tasks.
Higgsfield initially saw high adoption for viral, consumer-facing AI features but pivoted. They realized foundation model players like OpenAI will dominate and subsidize these markets. The defensible startup strategy is to ignore consumer virality and solve specific, monetizable B2B workflow problems instead.
Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.
An app bundling various LLMs into one interface is making $300k/month. Replicate this success by targeting a specific professional niche like lawyers or teachers. Stitch together models and workflows to become the default AI assistant for that vertical.
Most successful SaaS companies weren't built on new core tech, but by packaging existing tech (like databases or CRMs) into solutions for specific industries. AI is no different. The opportunity lies in unbundling a general tool like ChatGPT and rebundling its capabilities into vertical-specific products.
Counter to fears that foundation models will obsolete all apps, AI startups can build defensible businesses by embedding AI into unique workflows, owning the customer relationship, and creating network effects. This mirrors how top App Store apps succeeded despite Apple's platform dominance.
Successful vertical AI applications serve as a critical intermediary between powerful foundation models and specific industries like healthcare or legal. Their core value lies in being a "translation and transformation layer," adapting generic AI capabilities to solve nuanced, industry-specific problems for large enterprises.
Perplexity's CEO argues that building foundational models is not necessary for success. By focusing on the end-to-end consumer experience and leveraging increasingly commoditized models, startups can build a highly valuable business without needing billions in funding for model training.
The common critique of AI application companies as "GPT wrappers" with no moat is proving false. The best startups are evolving beyond using a single third-party model. They are using dozens of models and, crucially, are backward-integrating to build their own custom AI models optimized for their specific domain.
An AI application can be a powerful business, even as a 'wrapper,' if it serves a niche audience that is unlikely to use a frontier model like GPT directly. The defensibility comes not from unique technology but from a deeply tailored user experience for a specific market, such as language-learning for children.
