Product managers at large AI labs are incentivized to ship safe, incremental features rather than risky, opinionated products. This structural aversion to risk creates a permanent market opportunity for startups to build bold, niche applications that incumbents are organizationally unable to pursue.

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When evaluating AI startups, don't just consider the current product landscape. Instead, visualize the future state of giants like OpenAI as multi-trillion dollar companies. Their "sphere of influence" will be vast. The best opportunities are "second-order" companies operating in niches these giants are unlikely to touch.

Unlike cloud or mobile, which incumbents initially ignored, AI adoption is consensus. Startups can't rely on incumbents being slow. The new 'white space' for disruption exists in niche markets large companies still deem too small to enter.

The true economic revolution from AI won't come from legacy companies using it as an "add-on." Instead, it will emerge over the next 20 years from new startups whose entire organizational structure and business model are built from the ground up around AI.

Incumbents face the innovator's dilemma; they can't afford to scrap existing infrastructure for AI. Startups can build "AI-native" from a clean sheet, creating a fundamental advantage that legacy players can't replicate by just bolting on features.

Large platforms focus on massive opportunities right in front of them ('gold bricks at their feet'). They consciously ignore even valuable markets that require more effort ('gold bricks 100 feet away'). This strategic neglect creates defensible spaces for startups in those niche areas.

YC Partner Harsh Taggar suggests a durable competitive moat for startups exists in niche, B2B verticals like auditing or insurance. The top engineering talent at large labs like OpenAI or Anthropic are unlikely to be passionate about building these specific applications, leaving the market open for focused startups.

Many engineers at large companies are cynical about AI's hype, hindering internal product development. This forces enterprises to seek external startups that can deliver functional AI solutions, creating an unprecedented opportunity for new ventures to win large customers.

As the market leader, OpenAI has become risk-averse to avoid media backlash. This has “damaged the product,” making it overly cautious and less useful. Meanwhile, challengers like Google have adopted a risk-taking posture, allowing them to innovate faster. This shows how a defensive mindset can cede ground to hungrier competitors.

Periods of intense technological disruption, like the current AI wave, destabilize established hierarchies and biases. This creates a unique opportunity for founders from non-traditional backgrounds who may be more resilient and can identify market needs overlooked by incumbents.

Investing in startups directly adjacent to OpenAI is risky, as they will inevitably build those features. A smarter strategy is backing "second-order effect" companies applying AI to niche, unsexy industries that are outside the core focus of top AI researchers.