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Nykode finalized major deals with Genentech and Regeneron during COVID lockdowns over audio-only calls. Co-founder Agnete Friedrichsen believes this would have been impossible without the strong personal relationships and trust they had built through extensive face-to-face meetings prior to the pandemic.

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In early-stage enterprise sales, in-person meetings are crucial for building the trust needed to close deals. The founder should physically meet with early customers to build genuine relationships and navigate internal politics, which is difficult to do remotely.

After analyzing missed investment opportunities, Kleiner Perkins found a pattern: passing on good companies often involved meeting the founders only over Zoom. This led to a new internal heuristic that the first meeting with a founder must be in person to get a true visceral feel for their ambition.

Direct-to-founder sourcing requires comfort with the fact that most conversations won't lead to a deal. This work isn't wasted; it builds a network of trust and market intelligence. Founders are interesting people, and treating every interaction with respect builds long-term karma and reputation.

In-person meetings are fundamentally more effective for building trust than any amount of digital communication. This trust is the foundation for significant business decisions, as people buy from individuals and brands with whom they've had a positive, tangible experience.

As AI automates and personalizes digital outreach at scale, the market becomes incredibly noisy. A strategic way to stand out is to revert to traditional relationship-building. Flying to meet key stakeholders in person quickly establishes trust and provides a competitive edge that digital-only approaches cannot replicate.

For high-stakes enterprise sales in a crowded, opaque market like AI, traveling to meet clients in person is a powerful differentiator. It signals serious commitment, cuts through the noise of automated outbound, and builds the personal trust necessary to close large deals.

Turbine's pharma partners consistently praised the deep biological competence of its science team. This ability to engage as scientific peers, not just data scientists, built essential trust for early deals when the AI platform was still largely unvalidated.

To secure its first high-stakes enterprise design partners, Method Security made in-person meetings non-negotiable, even turning down opportunities that could only happen virtually. This tactic forced buyers to take them seriously and allowed the founding team to build the personal trust necessary for a large organization to bet on them.

As AI makes communication more generic, authentic human interaction becomes a powerful differentiator. Prioritizing physical meetings and personal relationships builds a level of trust that AI cannot replicate. This "human touch" is essential for establishing deep, meaningful partnerships that transcend digital efficiency and cut through the noise.

Vivtex's $2.1B deal with Novo Nordisk wasn't from a single pitch; it was cultivated over many years, stemming from pre-existing academic relationships. The key was building mutual scientific trust by consistently sharing progress—and even failures—allowing Novo Nordisk to observe their journey long-term.