The concept of a single best day and time to send an email is misleading. Instead, marketers should vary send times throughout the week to reach different segments of their audience. The key metric is the aggregate number of unique individuals engaged weekly, not the performance of a single blast.

Frame email subject lines to appeal to the higher-level position your audience desires. A manager wants to know what a CMO is doing. This psychological tactic, which plays on ambition, can lift open rates by 24-28% over standard personalization by speaking to who your audience wants to become.

From Nov 20th to Dec 20th, sending a personal letter-style email from a founder or executive to unengaged contacts can increase open rates by 40%. The key is changing the "from name" to a person, not the brand, and using a subject line that acknowledges their absence. This strategy works for both B2B and B2C brands.

Combine two specific audience identifiers in your subject line, like role and company attribute ("Mid-market CMOs") or interest and a pain point ("Beauty fans with sensitive skin"). This "double personalization" tactic reportedly increases B2B open rates by 24% and B2C by 29% by making the message feel hyper-relevant.

Email providers prioritize senders with high engagement. Sending at least five emails per month generates more opens and clicks, signaling credibility. This counterintuitively leads to higher average open rates and better inbox placement, contrary to the common fear of over-sending.

Focusing on email open rates can lead to clickbait subject lines and weak copy. Instead, orient your entire outreach strategy around getting a reply. This forces you to write more personalized, engaging content that addresses the recipient's specific pain points, leading to actual conversations, not just vanity metrics.

The common practice of having a fixed daily 'call block' (e.g., 9-10 AM) is fundamentally flawed. If your target prospect has a recurring meeting at that same time, you will never reach them. Effective prospecting requires dynamism; you must vary your outreach times throughout the week to maximize your chances of connecting.

Shift your primary success metric from passive opens to active replies. A reply signifies a genuine two-way conversation and a much deeper level of engagement. Actively inviting responses in your emails transforms a broadcast into a powerful relationship-building tool and provides invaluable audience feedback.

The idea of a single best time to send an email is outdated. Instead, measure success by the weekly aggregate of unique individuals opening your emails. Sending at various days and times hits different audience segments, maximizing your total reach over time.