Frame email subject lines to appeal to the higher-level position your audience desires. A manager wants to know what a CMO is doing. This psychological tactic, which plays on ambition, can lift open rates by 24-28% over standard personalization by speaking to who your audience wants to become.

A great cold email is judged on three criteria: 1) Packaging (subject line and preview text), 2) Body (personalization, problem/solution language, and social proof), and 3) Style (personal flair, formatting, and length). Mastering all three is key to getting replies.

Combine two specific audience identifiers in your subject line, like role and company attribute ("Mid-market CMOs") or interest and a pain point ("Beauty fans with sensitive skin"). This "double personalization" tactic reportedly increases B2B open rates by 24% and B2C by 29% by making the message feel hyper-relevant.

Both competitors used the names of the CRO's direct reports in their subject lines (e.g., "Idea for Mark and Larry's team"). This advanced tactic immediately signals deep, relevant research, showing an understanding of team structure and cutting through the noise of generic outreach.

To break through the noise, Astronomer used a subject line that simultaneously qualified the recipient and created intrigue. This direct, almost challenging, approach proved highly effective in capturing the attention of their specific target audience—Airflow users—and drove successful email campaigns.

AI-generated subject lines often use title case. Writing your subject line in all lowercase makes it feel more human and less automated, helping it stand out. This tactic can counter the generic feel of AI content and, according to World Data Research, can lift open rates by around 14%.

Switching from clear but safe subject lines (e.g., '3 ways to...') to provocative, curiosity-piquing ones dramatically improved open rates. The speaker notes that if a subject line feels slightly uncomfortable to send, it's probably a good sign.

A counterintuitive yet effective email tactic is capitalizing an entire word in the middle of a subject line, not at the start or end. This simple, cost-free A/B test is trending because it breaks visual patterns in the inbox, leading to a reported 16% open rate increase for B2B and 21% for B2C.

Contrary to the belief that holiday themes are unprofessional for B2B, incorporating playful, Halloween-related subject lines like "Don't ghost your leads" can boost email open rates by over 15%. This tactic is most effective when used in the 10 days leading up to the holiday.