Companies are now growing human brain cells on silicon chips and offering cloud API access for developers to code to them. This bio-compute model, which taught neurons to play a video game in a week, is vastly more energy-efficient than traditional GPU clusters, heralding a new computing paradigm.

To achieve 1000x efficiency, Unconventional AI is abandoning the digital abstraction (bits representing numbers) that has defined computing for 80 years. Instead, they are co-designing hardware and algorithms where the physics of the substrate itself defines the neural network, much like a biological brain.

Anthropic is pioneering a new hardware strategy. Instead of just renting Tensor Processing Units (TPUs) from Google Cloud, it is buying the chips directly from co-designer Broadcom. This gives Anthropic more control over its infrastructure, a significant move away from the standard cloud-centric model for AI companies.

The supply chain for neurons is not the main problem; they can be produced easily. The true challenge and next major milestone is "learning in vitro"—discovering the principles to program neural networks to perform consistent, desired computations like recognizing images or executing logic.

For a hyperscaler, the main benefit of designing a custom AI chip isn't necessarily superior performance, but gaining control. It allows them to escape the supply allocations dictated by NVIDIA and chart their own course, even if their chip is slightly less performant or more expensive to deploy.

Contrary to sci-fi imagery, the living neurons for biocomputing platforms are not extracted from animals. They are created from commercially available stem cells, which are originally derived from human skin. This process avoids the ethical and practical issues tied to using primary tissue.

Instead of only selling expensive hardware, Cortical Labs offers a cloud platform. This strategy lowers the accessibility barrier, enabling developers without labs to experiment and innovate, much like NVIDIA did with its free CUDA software.

Companies like Cortical Labs are growing human brain cells on chips to create energy-efficient biological computers. This radical approach could power future server farms and make personal 'digital twins' feasible by overcoming the massive energy demands of current supercomputers.

For zero-to-one technologies like humanoid robotics, relying on a supply chain is too slow. ONE X develops everything in-house, from new materials to foundation AI models. This enables rapid, cross-disciplinary iteration, as key discoveries happen at the intersection of hardware, software, and materials science.