Instead of defaulting to skepticism and looking for reasons why something won't work, the most productive starting point is to imagine how big and impactful a new idea could become. After exploring the optimistic case, you can then systematically address and mitigate the risks.

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When pursuing breakthrough ideas ("10x thinking"), the process is inherently uncomfortable. It's crucial to distinguish this discomfort, which signals you're pushing boundaries, from the feeling of being wrong. Embracing this discomfort is key to innovation in ambiguous, early-stage product development.

To vet ambitious ideas like self-sailing cargo ships, first ask if they are an inevitable part of the world in 100 years. This filters for true long-term value. If the answer is yes, the next strategic challenge is to compress that timeline and build it within a 10-year venture cycle.

Conventional innovation starts with a well-defined problem. Afeyan argues this is limiting. A more powerful approach is to search for new value pools by exploring problems and potential solutions in parallel, allowing for unexpected discoveries that problem-first thinking would miss.

To effectively leverage AI, treat it as a new team member. Take its suggestions seriously and give it the best opportunity to contribute. However, just like with a human colleague, you must apply a critical filter, question its output, and ultimately remain accountable for the final result.

AI models tend to be overly optimistic. To get a balanced market analysis, explicitly instruct AI research tools like Perplexity to act as a "devil's advocate." This helps uncover risks, challenge assumptions, and makes it easier for product managers to say "no" to weak ideas quickly.

Afeyan distinguishes risk (known probabilities) from uncertainty (unknown probabilities). Since breakthrough innovation deals with the unknown, traditional risk/reward models fail. The correct strategy is not to mitigate risk but to pursue multiple, diverse options to navigate uncertainty.

Innovators and hackers approach technology not by its intended function but by exploring its absolute limits and unintended capabilities. This "off-label use" mindset, which seeks to discover what a system can be forced to do, is the true root of breakthrough problem-solving.

Before starting a project, ask the team to imagine it has failed and write a story explaining why. This exercise in 'time travel' bypasses optimism bias and surfaces critical operational risks, resource gaps, and flawed assumptions that would otherwise be missed until it's too late.

Nubar Afeyan argues that companies should pursue two innovation tracks. Continuous innovation should build from the present forward. Breakthroughs, however, require envisioning a future state without a clear path and working backward to identify the necessary enabling steps.

Go beyond using AI for simple efficiency gains. Engage with advanced reasoning models as if they were expert business consultants. Ask them deep, strategic questions to fundamentally innovate and reimagine your business, not just incrementally optimize current operations.