Powerful AI models for biology exist, but the industry lacks a breakthrough user interface—a "ChatGPT for science"—that makes them accessible, trustworthy, and integrated into wet lab scientists' workflows. This adoption and translation problem is the biggest hurdle, not the raw capability of the AI models themselves.

A classical, bottom-up simulation of a cell is infeasible, according to John Jumper. He sees the more practical path forward as fusing specialized models like AlphaFold with the broad reasoning of LLMs to create hybrid systems that understand biology.

Language is just one 'keyhole' into intelligence. True artificial general intelligence (AGI) requires 'world modeling'—a spatial intelligence that understands geometry, physics, and actions. This capability to represent and interact with the state of the world is the next critical phase of AI development beyond current language models.

Startups and major labs are focusing on "world models," which simulate physical reality, cause, and effect. This is seen as the necessary step beyond text-based LLMs to create agents that can truly understand and interact with the physical world, a key step towards AGI.

The next leap in biotech moves beyond applying AI to existing data. CZI pioneers a model where 'frontier biology' and 'frontier AI' are developed in tandem. Experiments are now designed specifically to generate novel data that will ground and improve future AI models, creating a virtuous feedback loop.

In studying sperm whale vocalizations, an AI system trained on human languages did more than just process data. It actively "tipped off" researchers to look for specific spectral properties resembling human vowels. This highlights AI's evolving role in scientific discovery from a pure analytical tool to a source of hypothesis generation.

Dr. Fei-Fei Li cites the deduction of DNA's double-helix structure as a prime example of a cognitive leap that required deep spatial and geometric reasoning—a feat impossible with language alone. This illustrates that future AI systems will need world-modeling capabilities to achieve similar breakthroughs and augment human scientific discovery.

Following the success of AlphaFold in predicting protein structures, Demis Hassabis says DeepMind's next grand challenge is creating a full AI simulation of a working cell. This 'virtual cell' would allow researchers to test hypotheses about drugs and diseases millions of times faster than in a physical lab.

The next leap in AI will come from integrating general-purpose reasoning models with specialized models for domains like biology or robotics. This fusion, creating a "single unified intelligence" across modalities, is the base case for achieving superintelligence.