An 85-year Harvard study on adult life revealed that the strongest predictor of long-term health and happiness isn't wealth, fame, or power, but the quality of close relationships. Having even one person to count on is the key protective factor for a good life.

Self-compassion is not selfish; it cultivates a "balmier inner climate." This makes you less defensive and more available to others, improving your relationships. Since strong relationships are key to happiness, this positive external feedback then further improves your internal state, creating a positive feedback loop.

During major life transitions where your public identity is lost, having deep relationships with people who love you unconditionally provides a crucial anchor. This external validation, independent of your achievements, acts as a 'cheat code' for life, offering a stable sense of self-worth when you feel most lost.

Happiness studies reveal that fulfillment comes from the active process of caring for others. The happiest individuals are not those who are the passive recipients of the most affection, but rather those who actively cultivate deep, meaningful relationships where they can give love.

The key to a successful long-term relationship isn't just chemistry; it's a partner's psychological stability. This is measured by how quickly they return to their emotional baseline after a setback. This resilience is more predictive of success than more fleeting traits.

A leader's success and happiness can be measured by the loyalty and longevity of their team. Bill Maher, despite not having children, has built a 'family' with staff who have stayed for decades. This demonstrates that providing opportunities for others to give love and feel loyalty is a greater source of happiness than receiving it.

Negative comments and actions are disproportionately powerful, acting like "poison in our system." Research by relationship expert John Gottman indicates that a 5:1 ratio of positive to negative interactions is required to maintain a healthy emotional bank account with colleagues, reports, or family.

Citing Warren Buffett, the host posits that choosing a life partner is the most critical decision, with no close second. The panel agrees, emphasizing that a supportive partner who pushes you to be better is a fundamental driver of long-term personal and professional success.

The success of a long-term relationship is better predicted by how partners handle conflict and disagreement than by how much they enjoy good times together. People are more likely to break up due to poor conflict resolution than a lack of peak experiences.