To build a useful multi-agent AI system, model the agents after your existing human team. Create specialized agents for distinct roles like 'approvals,' 'document drafting,' or 'administration' to replicate and automate a proven workflow, rather than designing a monolithic, abstract AI.

AI's most significant impact won't be on broad population health management, but as a diagnostic and decision-support assistant for physicians. By analyzing an individual patient's risks and co-morbidities, AI can empower doctors to make better, earlier diagnoses, addressing the core problem of physicians lacking time for deep patient analysis.

The next evolution in personalized medicine will be interoperability between personal and clinical AIs. A patient's AI, rich with daily context, will interface with their doctor's AI, trained on clinical data, to create a shared understanding before the human consultation begins.

OpenAI's health division serves a dual purpose: delivering societal benefits and providing a real-world, high-stakes environment for AI safety research. Problems like scalable oversight (supervising superhuman AI) move from theoretical exercises to practical necessities when models outperform physicians on narrow tasks, creating concrete feedback loops that accelerate safety progress.

In a partnership with Kenya's Penda Health, OpenAI conducted the first randomized controlled trial of an LLM co-pilot for physicians. The study demonstrated a statistically significant improvement in diagnosis and treatment outcomes for patients whose doctors used the AI assistant. This provides crucial real-world evidence that AI can move beyond lab benchmarks to tangibly improve care.

An effective AI strategy in healthcare is not limited to consumer-facing assistants. A critical focus is building tools to augment the clinicians themselves. An AI 'assistant' for doctors to surface information and guide decisions scales expertise and improves care quality from the inside out.

In a sign of recursive capability improvement, OpenAI found that its model-based grader for the HealthBench evaluation benchmark was more accurate and consistent than the average human physician performing the same grading task. This demonstrates that models can not only perform a task but also evaluate that performance at a superhuman level, a key component of scalable oversight.

The creation of ChatGPT Health was not a proactive pivot but a direct response to massive, organic user behavior. OpenAI discovered that 1 in 4 weekly active users—over 200 million people globally—were already using the general purpose tool for health queries, validating the immense market demand before a single line of dedicated code was written.

Frontier AI models excel in medicine less because of their encyclopedic knowledge and more because of their ability to integrate huge amounts of context. They can synthesize a patient's entire medical history with the latest research—a task difficult for any single human. This highlights that the key to unlocking AI's value is feeding it comprehensive data, as context is the primary driver of superhuman performance.