For executives to truly drive AI adoption, simply using the tools isn't enough. They must model three key behaviors: publicly setting a clear vision for AI's role, actively participating in company-wide learning initiatives like hackathons, and empowering employees with the autonomy to experiment.

Z.AI's culture mandates that technical leaders, including the founder, remain hands-on practitioners. The AI field evolves too quickly for a delegated, hands-off management style to be effective. Leaders must personally run experiments and engage with research to make sound, timely decisions.

AI is a 'hands-on revolution,' not a technological shift like the cloud that can be delegated to an IT department. To lead effectively, executives (including non-technical ones) must personally use AI tools. This direct experience is essential for understanding AI's potential and guiding teams through transformation.

The next leap in biotech moves beyond applying AI to existing data. CZI pioneers a model where 'frontier biology' and 'frontier AI' are developed in tandem. Experiments are now designed specifically to generate novel data that will ground and improve future AI models, creating a virtuous feedback loop.

CZI’s mission to cure all diseases is seen as unambitious by AI experts but overly ambitious by biologists. This productive tension forces biologists to pinpoint concrete obstacles and AI experts to grasp data complexity, accelerating the overall pace of innovation.

According to Techstars' CEO David Cohen, standout AI companies are defined by their leadership. The CEO must personally embody an "AI-first" mindset, constantly thinking about leverage and efficiency from day one. It's not enough to simply lead a team of engineers who understand AI; the strategic vision must originate from the top.

Companies mistakenly try to hire one person for both applying AI in products and building the underlying AI infrastructure. These are two distinct roles requiring different skill sets. A VP of Engineering leverages existing AI for efficiency, while a Head of AI builds the core platforms for the company.

CZI operates at the intersection of two cultures: biologists who saw their goals as "crazy ambitious" and AI experts who saw them as "boring" and inevitable. Their strategy is to actively merge these fields to create breakthroughs that neither could achieve alone.

Instead of funding small, incremental research grants, CZI's philanthropic strategy focuses on developing expensive, long-term tools like AI models and imaging platforms. This provides leverage to the entire scientific community, accelerating the pace of the whole field.