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A study by Dr. Ben Levine revealed that a two-year regimen of four hours of varied exercise per week turned 50-year-old hearts into 30-year-old hearts. This plasticity is lost after age 65, making midlife the critical window to remodel the heart and reverse age-related defects.

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A landmark study by Dr. Ben Levine showed a protocol of varied, moderate-to-rigorous exercise for four hours a week could remodel the heart of a 50-year-old to resemble that of a 30-year-old. This cardiac plasticity, however, has an 'expiration date' around age 65.