When evaluating AI startups, don't just consider the current product landscape. Instead, visualize the future state of giants like OpenAI as multi-trillion dollar companies. Their "sphere of influence" will be vast. The best opportunities are "second-order" companies operating in niches these giants are unlikely to touch.

Startups like Cognition Labs find their edge not by competing on pre-training large models, but by mastering post-training. They build specialized reinforcement learning environments that teach models specific, real-world workflows (e.g., using Datadog for debugging), creating a defensible niche that larger players overlook.

While foundational AI models threaten broad applications like writing aids, startups can thrive by focusing on vertical-specific needs. Building for niche workflows, compliance, and deep integrations creates a moat that large, generalist AI companies are unlikely to cross.

For entrepreneurs building on top of large language models, the key differentiator is not creating general platforms but achieving deep domain specialization. The call to arms is to know a vertical better than anyone and imbue that unique knowledge into AI agents, creating a defensible moat against more generalized tools.

To avoid being crushed by AI platform advancements, startups shouldn't compete directly with core models ('under the rock'). Instead, they should find a specific, underserved problem on the outer edge of what's newly possible, where deep user familiarity provides a defensible moat.

Despite the dominance of large AI labs, they face constraints in compute, talent, and focus. Startups can thrive by building highly specialized products for verticals the big players deem too niche. This focused approach allows them to build better interfaces and achieve deeper market penetration where giants won't prioritize competing.

YC Partner Harsh Taggar suggests a durable competitive moat for startups exists in niche, B2B verticals like auditing or insurance. The top engineering talent at large labs like OpenAI or Anthropic are unlikely to be passionate about building these specific applications, leaving the market open for focused startups.

A VC offers an analogy for competing with AI giants like OpenAI: they are 'Godzilla.' Instead of direct confrontation, startups should 'find an alleyway to hide in.' This means focusing on niche applications or non-software domains where they won't be 'stomped' by inevitable foundation model improvements.

Investing in startups directly adjacent to OpenAI is risky, as they will inevitably build those features. A smarter strategy is backing "second-order effect" companies applying AI to niche, unsexy industries that are outside the core focus of top AI researchers.