The phase 3 EPCOR FL-1 trial showed that adding epcoritamab to the lenalidomide/rituximab (R-squared) backbone profoundly improved progression-free survival in relapsed follicular lymphoma. Presented as the most important FL abstract at ASH, this result is expected to establish a new standard of care in this setting.

A modified three-step-up dosing schedule for epcoritamab drastically reduced cytokine release syndrome (CRS) rates to 26%, with no severe events. This safety profile supports fully outpatient administration, making this highly effective regimen accessible to community practices without immediate hospital access.

Beyond approving the triplet combination, the positive Epcor FL1 trial data had a significant ripple effect. It solidified the drug's overall profile, leading to the conversion of its prior provisional (accelerated) approvals for monotherapy in follicular lymphoma and DLBCL into full, traditional approvals.

As CAR-T cell therapies are increasingly adopted for second-line treatment of large cell lymphoma, epcoritamab is solidifying its role as a critical, potentially curative replacement option in the third-line setting. This establishes a clear sequential treatment pathway for patients who continue to relapse.

The regimen's profound success in relapsed/refractory patients is not an endpoint, but a launchpad. It provides the rationale for the ongoing Epcor FL2 trial, which directly challenges standard chemoimmunotherapy and could establish a chemotherapy-free, bispecific-based combination as the new first-line standard of care.

The term "functional cure" is misleading and hinders progress. With one-third of heavily pretreated patients in the Cartitude 1 trial remaining disease-free for five years without maintenance, the data supports the classical definition of a "cure" used in other cancers. This semantic shift is crucial for advancing the field.

Long-term follow-up from the pivotal epcoritamab trial reveals that 46% of DLBCL patients who achieve a complete remission maintain it at four years. This durability provides strong evidence that bispecific monotherapy, not just CAR-T, can be a curative treatment for a subset of patients.

A new class of oral drugs, BCL6 degraders, are demonstrating complete remissions as a single agent in heavily pretreated aggressive lymphoma patients. This activity was surprising, as they were initially expected to require combination therapy to be effective, signaling a promising new non-cell surface targeting mechanism.

The dramatic efficacy boost from adding epcoritamab suggests it's the primary driver of patient benefit, not just an adjunct. This shifts the conceptual framework, positioning the bispecific antibody as the new therapeutic backbone, with rituximab and lenalidomide as supportive agents.