The pursuit of pure originality is often a status game that leads to incomprehensible ideas. A more effective approach is to see originality as a new way to show people an old, constant truth. This re-frames innovation as a novel form of derivation, making it more accessible and relatable.

Predicting the future is hard. Instead, focus on foundational truths that will remain constant. Bezos knew customers would always want lower prices and faster delivery. Building a business around these unchanging principles is a more robust strategy than chasing fleeting trends.

Successful MedTech innovation starts by identifying a pressing, real-world clinical problem and then developing a solution. This 'problem-first' approach is more effective than creating a technology and searching for an application, a common pitfall for founders with academic backgrounds.

Instead of chasing trends or pivoting every few weeks, founders should focus on a singular mission that stems from their unique expertise and conviction. This approach builds durable, meaningful companies rather than simply chasing valuations.

Many business struggles are not unique problems but are inherent features of the industry itself, like labor shortages in cleaning or client motivation in fitness. Recognizing this shifts focus from trying to "solve" the unsolvable to managing the dichotomy effectively.

A crucial piece of advice for biotech founders is to interact with patients as early as possible. This 'patient first' approach helps uncover unmet needs in their treatment journey, providing a more powerful and differentiated perspective than focusing solely on the scientific or commercial landscape.

The rapid pace of AI innovation means today's cutting-edge research is irrelevant in three months. This creates a core challenge for founders: establishing a stable, long-term company vision when the underlying technology is in constant, rapid flux. The solution is to anchor on the macro trend, not the specific implementation.

Instead of chasing futuristic 'shiny objects,' the most impactful digital initiatives solve tangible, existing problems. For example, using an AI model to predict when pharmacists will run out of medication directly prevents lost sales and improves the patient experience.

A principle from fashion states that successful product iterations typically change only one core element at a time. Introducing two or three significant changes at once often fails because it overwhelms the consumer. This 'one egg' rule forces focus on the most impactful innovation.