For leaders overwhelmed by AI, a practical first step is to apply a lean startup methodology. Mobilize a bright, cross-functional team, encourage rapid, messy iteration without fear, and systematically document failures to enhance what works. This approach prioritizes learning and adaptability over a perfect initial plan.

Unlike traditional software development, AI-native founders avoid long-term, deterministic roadmaps. They recognize that AI capabilities change so rapidly that the most effective strategy is to maximize what's possible *now* with fast iteration cycles, rather than planning for a speculative future.

Treat AI initiatives as two separate strategic pillars. Create one roadmap focused on internal efficiency gains and cost reduction (productivity). Maintain a separate roadmap for developing new, revenue-generating customer experiences (growth). This prevents conflating internal tools with external products.

In a gold rush like AI, the shared 'why now' forces many founders into a pure speed-based strategy. This is a dangerous game, as it often lacks long-term defensibility and requires an incredibly hard-charging approach that not all teams can sustain.

To innovate quickly without being bogged down by technical debt, portfolio companies should ring-fence new AI development. By outsourcing it and treating it as a separate "skunk works" project, the core tech team can focus on existing systems while the new initiative succeeds or fails on its own merits.

The rapid pace of AI makes traditional, static marketing playbooks obsolete. Leaders should instead foster a culture of agile testing and iteration. This requires shifting budget from a 70-20-10 model (core-emerging-experimental) to something like 60-20-20 to fund a higher velocity of experimentation.

OpenAI operates with a "truly bottoms-up" structure because it's impossible to create rigid long-term plans when model capabilities are advancing unpredictably. They aim fuzzily at a 1-year+ horizon but rely on empirical, rapid experimentation for short-term product development, embracing the uncertainty.

Afeyan advises against making breakthrough innovation everyone's responsibility, as it's unsustainable and disruptive to daily jobs. Instead, companies should create a separate group with different motivations, composition, and rewards, focused solely on discontinuous leaps.

In the fast-moving AI sector, quarterly planning is obsolete. Leaders should adopt a weekly reassessment cadence and define "boundaries for experimentation" rather than rigid goals. This fosters unexpected discoveries that are essential for staying ahead of competitors who can leapfrog you in weeks.