When Tubulus pivoted its lead program from liquid to solid tumors, the team's ability to change direction instantly stemmed directly from the company's foundational culture of trust. Openly explaining the rationale behind major strategic decisions allows employees to follow and execute without friction, even on a dime.

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For a controversial strategic shift, a co-founder's "moral authority" is invaluable. They can absorb the risk of looking foolish and give up their responsibilities ("Legos") to spearhead a new initiative. This allows them to champion a new direction with a level of credibility that can overcome internal skepticism.

To secure buy-in for its risky "Platform 2," Zipline built a rough prototype and held a "conviction milestone" event for the whole company. Witnessing the tangible demo converted even the most ardent skeptics on the leadership team, aligning everyone to bet the company's future on the new product.

As a company grows, new hires lack the context of early struggles. To preserve the original culture, formally document and share stories of early failures, pivots, and near-death experiences during onboarding. This reminds everyone of the core principles that led to success.

Managerial companies derive legitimacy from "the plan," creating enormous inertia against change. In founder-led companies, legitimacy is vested in the founder as an individual. This is their key structural advantage, allowing the entire organization to pivot on a dime based on conviction.

The Browser Company's pivot required spending the "trust points" they'd built with their team and community. Leaders must be prepared for this painful drawdown and the internal/external backlash, even when they have high conviction in the new direction. It's a necessary but difficult part of a major strategic shift.

The long-standing relationship between PhonePe's co-founders, built on deep trust, allows them to be interchangeable in their roles. This enables one to step back during difficult periods while the other steps in, ensuring resilience through crises.

Brian Halligan recounts advice from iRobot's CEO that transformed his view on culture. He realized culture isn't a soft concept but a critical scaling mechanism; it's the operating system that guides employees' decisions when leaders aren't present, ensuring consistency as the organization grows.

To manage the psychological difficulty of abandoning a working product with paying customers, Fal's founders convinced themselves their pivot wasn't a drastic change but just a shift in workload. This mental reframing helped them overcome the inertia and social pressure associated with a major strategic change, allowing them to pursue the much larger opportunity in AI inference.

A biotech transitioning from a small, 'fit-for-purpose' R&D team to a large commercial organization gets a rare chance to create a new culture. Madrigal treated its rapid growth from ~100 to over 500 people as an opportunity to establish fresh core values for the newly-formed enterprise.

When hypergrowth causes you to fail internal stakeholders (like Operations), apologies are insufficient. Rebuild trust by going to the CEO and board *together* with the slighted team to advocate for a drastic roadmap pivot that prioritizes their needs, demonstrating true commitment to their success.