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Industrial strategy is more effective when focused on solving big problems, like creating healthy school lunches or landing on the moon. This "mission-oriented" approach stimulates innovation across many sectors, unlike traditional policy that just hands subsidies to favored industries.

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The most effective government role in innovation is to act as a catalyst for high-risk, foundational R&D (like DARPA creating the internet). Once a technology is viable, the government should step aside to allow private sector competition (like SpaceX) to drive down costs and accelerate progress.

Buttigieg argues the government's essential function is investing in foundational, high-risk ideas like the internet or basic research. These ventures have massive potential but don't offer the short-term returns or clear monetization paths required by the private sector due to market failures.

Describing space exploration as a 'cash grab' isn't cynical; it's a recognition of fundamental human motivation. Money acts as 'proof of work,' incentivizing people to dedicate time and resources to difficult, long-term goals. Without a profit motive, ambitious endeavors like becoming a multi-planetary species would never attract the necessary capital and talent.

NASA spurred massive innovation by shifting from cost-plus contracts to "outcomes-oriented procurement." Instead of dictating specifications, they defined problems—like how astronauts would eat or use the bathroom in space—and challenged the private sector to invent solutions, leading to numerous commercial spin-offs.

A moonshot isn't just a big goal. It requires three parts: a major global problem, a sci-fi sounding solution that would solve it, and a specific breakthrough technology that makes the solution seem just barely possible. This framework creates a testable hypothesis.

Frame moonshot projects like Google's Waymo not as singular bets, but as platforms for innovation. Even if the primary goal fails, the project should be structured to spin off valuable 'side effects'—advances in component technologies like AI, mapping, or hardware that benefit the core business.

A complete national industrial strategy requires a dual approach. It needs large, congressionally-approved programs for trillion-dollar sectors like semiconductors, paired with a smaller, more flexible fund to quickly address emerging choke points in smaller markets like rare earths or APIs without new legislation each time.

To rebuild its industrial base at speed, the US government must abandon its typical strategy of funding many small players. Instead, it should identify and place huge bets on a handful of trusted, patriotic entrepreneurs, giving them the scale, offtake agreements, and backing necessary to compete globally.

Investments in large-scale scientific programs like the Apollo mission are not sunk costs but economic multipliers. Historically, every dollar spent has generated a significant return in broader economic growth, providing a strong financial argument for ambitious, long-term R&D.

Pharmaceutical companies are incentivized to create treatments for chronic diseases, not one-time cures that eliminate revenue streams. This market failure makes "cure" research a prime candidate for public funding, similar to ambitious projects like the original moon landing.