During product discovery, Amazon teams ask, "What would be our worst possible news headline?" This pre-mortem practice forces the team to identify and confront potential weak points, blind spots, and negative outcomes upfront. It's a powerful tool for looking around corners and ensuring all bases are covered before committing to build.

For leaders overwhelmed by AI, a practical first step is to apply a lean startup methodology. Mobilize a bright, cross-functional team, encourage rapid, messy iteration without fear, and systematically document failures to enhance what works. This approach prioritizes learning and adaptability over a perfect initial plan.

Conventional innovation starts with a well-defined problem. Afeyan argues this is limiting. A more powerful approach is to search for new value pools by exploring problems and potential solutions in parallel, allowing for unexpected discoveries that problem-first thinking would miss.

Instead of optimizing for a quick win, founders should be "greedy" and select a problem so compelling they can envision working on it for 10-20 years. This long-term alignment is critical for avoiding the burnout and cynicism that comes from building a business you're not passionate about. The problem itself must be the primary source of motivation.

In AI, low prototyping costs and customer uncertainty make the traditional research-first PM model obsolete. The new approach is to build a prototype quickly, show it to customers to discover possibilities, and then iterate based on their reactions, effectively building the solution before the problem is fully defined.

Inspired by James Dyson, Koenigsegg embraces a radical commitment to differentiation: "it has to be different, even if it's worse." This principle forces teams to abandon incremental improvements and explore entirely new paths. While counterintuitive, this approach is a powerful tool for escaping local maxima and achieving genuine breakthroughs.

A visionary founder must be willing to shelve their ultimate, long-term product vision if the market isn't ready. The pragmatic approach is to pivot to an immediate, tangible customer problem. This builds a foundational business and necessary ecosystem trust, paving the way to realize the grander vision in the future.

Afeyan distinguishes risk (known probabilities) from uncertainty (unknown probabilities). Since breakthrough innovation deals with the unknown, traditional risk/reward models fail. The correct strategy is not to mitigate risk but to pursue multiple, diverse options to navigate uncertainty.

Moving from a science-focused research phase to building physical technology demonstrators is critical. The sooner a deep tech company does this, the faster it uncovers new real-world challenges, creates tangible proof for investors and customers, and fosters a culture of building, not just researching.