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  1. All-In with Chamath, Jason, Sacks & Friedberg
  2. Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton
Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg · Sep 30, 2025

Science Corner explores optimistic tech with Cleo Abram, cosmic origins via the JWST, and life-saving delivery drones from Zipline's CEO.

The Absence of Aliens Suggests Humanity's "Great Filter" Is Still to Come

The Fermi Paradox—where are the aliens?—can be explained by the "Great Filter" theory. Astrophysicist Alex Filippenko believes this filter is likely in our future, meaning civilizations like ours often destroy themselves before colonizing the galaxy.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Finding Both Oxygen and Methane on an Exoplanet Would Be a Telltale Sign of Life

The search for extraterrestrial life focuses on "chemical disequilibrium." The simultaneous presence of oxygen and methane in an exoplanet's atmosphere would be a strong indicator of life, as they naturally destroy each other, implying a constant biological source is replenishing them.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Streamers Like Netflix Now Treat YouTube as an IP Incubator for New Shows

Traditional media companies are turning to successful YouTube creators to source proven concepts and talent. They offer upfront capital to scale existing YouTube IP into larger productions, creating a symbiotic relationship between once-separate platforms.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Zipline's U.S. Growth Is Driven by Viral TikToks, Not Paid Marketing

After turning off paid marketing, Zipline's growth continued to accelerate. The CEO discovered that the spectacle of a robot delivering items to a home is inherently shareable content, with customers' viral TikTok videos becoming its most effective and free marketing channel.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

The James Webb Telescope Cost Each U.S. Taxpayer Only One $6 Hamburger Per Year

Astrophysicist Alex Filippenko puts the telescope's $10 billion price tag into perspective. Spread over its 10-year development and the U.S. taxpayer base, the cost for this monumental scientific achievement was surprisingly minimal for each individual.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Today's Tech Industry Was Built on Yesterday's "Useless" Quantum Physics Research

Pure, curiosity-driven research into quantum physics over a century ago, with no immediate application in sight, became the foundation for today's multi-billion dollar industries like lasers, computer chips, and medical imaging. This shows the immense, unpredictable ROI of basic science.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Today's Delivery Model Uses a 4,000-Pound Car to Move a 5-Pound Package

Zipline's CEO argues from first principles that current delivery logistics are absurdly inefficient. Replacing a human-driven, gas-powered car with a small, autonomous electric drone is not just an incremental improvement but a fundamental paradigm shift dictated by physics.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Zipline's CEO Says Users Go From "Sci-Fi Amazement" to "Entitlement" in Just 7 Days

New technology is magical for about a week before it becomes a mundane utility. A nurse complaining that a life-saving blood delivery drone was 30 seconds late illustrates how quickly users normalize revolutionary services and build new, higher expectations.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

YouTuber Cleo Abram Gained 6M Subscribers by Serving an Audience Tired of Media Pessimism

Cleo Abram's channel "Huge If True" proves a large, untapped market exists for optimistic content. She went independent from Vox to tell stories about positive technological progress, discovering millions who were similarly fatigued by media's dominant pessimistic narrative.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Zipline's Drone Delivery System Cut Maternal Mortality in Rwanda by 51%

Zipline's CEO Keller Rinaudo Cliffton reveals their service's profound public health impact. By providing rapid, on-demand delivery of blood transfusions to remote hospitals, the autonomous system directly addressed a leading cause of maternal death, proving robotics can solve critical global issues.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago

Zipline Launched in Rwanda Because Its Government Was More Entrepreneurial Than the U.S.

CEO Keller Rinaudo Cliffton explains that developing nations can be superior markets for launching disruptive tech. Rwanda's regulatory agility and hunger to adopt new paradigms allowed Zipline to deploy and prove its technology faster than would have been possible in the U.S.

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton thumbnail

Science Corner Special: David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton

All-In with Chamath, Jason, Sacks & Friedberg·5 months ago