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  1. Masters of Scale
  2. Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm
Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale · Dec 23, 2025

Colossal Biosciences CEO Ben Lamb discusses resurrecting the dire wolf, the ethics of de-extinction, and building a $10B business on sci-fi tech.

Colossal Biosciences' Deep Tech Model: Monetize Spinoffs, Not the Core Product

Colossal generates value not by selling resurrected animals but by spinning out valuable technology companies developed during its R&D, such as a computational biology platform. The long-term vision involves biodiversity credits rather than direct sales.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago

Colossal Defines "Functional De-Extinction" as Genetic Engineering, Not Cloning

Colossal clarifies its process is not true cloning but "functional de-extinction." It involves editing the genome of a close living relative (like a gray wolf) to reintroduce the specific genes and traits of an extinct species, using the living animal as a 99%+ genetic base.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago

Colossal Reframes the "Playing God" Debate as a Moral Obligation to Act

CEO Ben Lamb counters ethical criticism by arguing that humanity is already negatively "playing God" by causing mass extinction. He posits a moral obligation to use technology to reverse the damage we've caused, turning the common critique on its head.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago

De-Extinction Projects Attract PR, but Saving Endangered Species Is the Real Work

Colossal's CEO admits that headline-grabbing projects like the dire wolf overshadow more impactful but less "sexy" work, such as saving the critically endangered red wolf. The glamorous projects act as a funnel for attention and funding for broader conservation efforts.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago

Frontier Tech Companies Must Proactively Build Their Own Ethical Frameworks

Facing immense ethical questions about technologies like artificial wombs, Colossal doesn't wait for regulation. It establishes its own clear, public guardrails—such as refusing to work on humans or primates and tying every project back to conserving an existing endangered species.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago

A Tech Entrepreneur's Outsider Perspective Unlocked a Stagnant Scientific Field

Colossal CEO Ben Lamb, a software entrepreneur with no biology background, approached top geneticist George Church seeking world-changing problems. His ability to build teams and secure capital, unconstrained by scientific dogma, was key to launching the ambitious de-extinction venture.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago

Semantic Debates Over Scientific Breakthroughs Can Obscure the Actual Achievement

Colossal CEO Ben Lamb argues that the scientific community's debate over whether his creation is a "true" dire wolf is a semantic distraction. He contends this argument overshadows the unprecedented scientific milestone of creating live animals from 12,000-year-old DNA.

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm thumbnail

Resurrecting dire wolves is just the beginning for Colossal Biosciences’ Ben Lamm

Masters of Scale·3 months ago