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  1. Modern Wisdom
  2. Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102
Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom · May 25, 2026

Andrew Huberman, Tom Segura & Matt McCusker discuss ED meds for prostate health, the art of comedian-actors, and modern conspiracy theories.

The Male Refractory Period Can Be Shortened by Blunting Prolactin with Vitamin B6

After orgasm, the hormone prolactin increases, causing the refractory period. Neuroscientist Andrew Huberman explains that this response can be blunted. Supplements like P5P (a form of vitamin B6) can inhibit prolactin to a degree, thereby shortening the refractory period and allowing for quicker subsequent arousal.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Linking a Food's Shape to Its Health Benefit Is a Form of Pseudo-Psychotic Reasoning

The belief that a food is good for an organ because it resembles it (e.g., walnuts for the brain) is a "visual clang association," a reasoning pattern common in psychosis. Neuroscientist Andrew Huberman identifies this as a flawed heuristic in the wellness world, where superficial similarities are mistaken for causal relationships.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Comedians Struggle with Acting Due to Lack of Immediate Audience Feedback

Unlike stand-up comedy where laughter provides instant validation, acting on a set offers little to no real-time feedback. Experienced actors are confident without it, but comedians, accustomed to immediate audience reaction, often seek approval from the director after a take, revealing their insecurity in the new medium.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Reality TV Producers Manipulate Contestants By Removing All Sense of Time

To control the narrative and sleep patterns, reality show producers create a disorienting environment. They confiscate phones, remove clocks from the set, and even alter the time on car radios during off-site trips. This sensory deprivation makes contestants more malleable and ensures they are rested or agitated as needed for storylines.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Ubiquitous Cameras May Explain the Disappearance of Long-Term Serial Killers

The classic serial killer who evades capture for decades may be a relic of a pre-digital era. The proliferation of private and public cameras, from Ring doorbells to tollbooth monitors, creates a digital footprint that makes it much harder for criminals to operate anonymously over long periods, leading to faster captures.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Comedians Use Post-Show Rituals to Manage Intense Adrenaline Crashes

Performing stand-up comedy creates a massive spike in catecholamines (dopamine, adrenaline), leaving comedians highly aroused post-show. To transition from this peak state to rest, they often rely on rituals like drinking, eating, or masturbation to trigger a parasympathetic (rest and digest) response and manage the biochemical comedown.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Viagra's Efficacy Was Discovered When Trial Participants Refused to Return the Drug

Viagra was originally tested as a heart medication for angina. Researchers realized its potent side effect when, contrary to typical trial behavior, male participants were reluctant to return the leftover pills and were observed sitting awkwardly to conceal erections. This user behavior signaled a massive alternative market.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Comedy Is an Art Form That Uniquely Resists Acquired Taste

While you can learn to appreciate complex music or art, comedy elicits a more involuntary, immediate reaction. If a joke doesn't land, explanations won't make it funny, and repetition makes it worse. This makes humor uniquely subjective on a per-joke basis, even if legendary comedians are considered objectively great.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Viral Videos Have Raised the Public's Threshold for Believing Accusations

In an era of constant surveillance, the public's standard of proof has shifted. Neuroscientist Andrew Huberman argues that incidents captured on video have conditioned society to demand visual evidence. Mere accusations or reports are now treated as chatter until a definitive video emerges, raising the bar for what is considered truth.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

The Stanford Marshmallow Test Is Misunderstood: No Child Actually Waited the Full Time

The popular understanding of the Stanford marshmallow experiment is flawed. The critical, and often omitted, detail is that every child in the study ate the first marshmallow before the 15-minute timer ended. The predictive power came from measuring *how long* a child could delay gratification, not whether they could resist temptation completely.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Low-Dose Cialis (Tadalafil) Is Recommended for Prostate Health in Men Over 40

Neuroscientist Andrew Huberman explains that Tadalafil, originally a prostate health drug, improves blood perfusion at low doses (2.5-5mg). A Stanford urologist suggests most men over 40 could benefit from this daily regimen, framing it as a health measure rather than just for erectile dysfunction.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Severe Circadian Disruption in Hospitals Can Cause Temporary "ICU Psychosis"

"ICU psychosis" is a known phenomenon where patients in intensive care units develop genuine psychotic symptoms. The constant light, noise, and fractured sleep patterns severely disrupt their circadian rhythms. This illustrates the critical role of a stable sleep-wake cycle in maintaining mental sanity, as the psychosis often resolves upon discharge.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Marc Andreessen's "Retard Maxing" Philosophy Prioritizes Action Over Introspection

"Retard maxing" is a counter-cultural philosophy championing action over self-reflection. It suggests that over-analyzing problems and emotions leads to paralysis. Instead, one should just "handle your business" and ignore distracting thoughts, a concept venture capitalist Marc Andreessen believes was common among great historical figures.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Sunlight's Long-Wavelength Rays Are Essential for Mitochondrial Health

Beyond just Vitamin D, sunlight provides critical long-wavelength light (red and infrared) that benefits cellular mitochondria. This "good stuff" can even penetrate light clothing. In contrast, modern indoor environments are dominated by short-wavelength, blue-shifted LED lights, creating an imbalanced light diet that may negatively impact our cellular energy production.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago

Your Wearable's Sleep Score Creates a Placebo Effect on Daily Performance

Research shows a strong placebo effect tied to sleep scores from wearables. Seeing a high score can boost your cognitive and physical performance even after a mediocre night's sleep. Conversely, a poor score can diminish performance even if you slept well. The perception of sleep quality significantly impacts real-world ability.

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102 thumbnail

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

Modern Wisdom·6 days ago