Contrary to concerns from animal studies about endocrine disruption, human data and Dr. D'Agostino's self-experimentation with high doses (up to 30mg) show no suppression of key hormones like testosterone, LH, or FSH. This suggests it can be used safely for its neuroprotective and antioxidant benefits.

Melatonin is not a sedative; it's a hormone that signals to your brain that it's nighttime. Meta-analyses show it only reduces the time to fall asleep by about 3-4 minutes. Its primary effective uses are for managing jet lag or specific circadian rhythm disorders.

Most people have sex at night when hormonal profiles are misaligned for intimacy (low testosterone, high melatonin). In the morning, key hormones like testosterone and cortisol are high while melatonin is low, leading to biologically superior performance and connection.

Casein, a primary protein in milk, can function as a mu opioid receptor agonist within the gut. This activity can lead to an increase in prolactin levels, which in turn can suppress dopamine and the hormones that stimulate testosterone production.

When addressing hormone imbalances, start at the base of the "hormone pyramid." Optimizing foundational hormones like cortisol (stress) and insulin (blood sugar) is essential, as they directly impact thyroid function and sex hormones like estrogen and testosterone.

Early pubertal timing in girls—more so than the rate of development—is a strong predictor of future health risks, including mental health issues, earlier menopause, and a shorter lifespan. This suggests a deep biological trade-off between reproductive maturity and longevity, observed across species.

Melatonin isn't just for sleep; its release duration changes with seasonal light exposure. This acts as a hormonal calendar, signaling the time of year to your entire body and influencing major biological functions.

Your wake-up time triggers a 14-hour countdown for melatonin release that evening. By waking up at the same time seven days a week, you anchor your circadian rhythm, ensuring you naturally feel tired at the right time each night. Bedtime consistency is secondary.

Melatonin is a hormone, not a simple sleep aid. Studies show over-the-counter products can contain 0% to 667% of the listed dose. It dangerously interacts with SSRIs and birth control, and high doses can act as a contraceptive, potentially disrupting puberty in children.