Contrary to Econ 101's labor-leisure tradeoff, unconditional cash transfers consistently lead to an increase in work in low-income countries. Recipients are capital-constrained, and the cash enables them to start small businesses, leading to a zero or positive effect on labor supply.

A paradoxical market reality is that sectors with heavy government involvement, like healthcare and education, experience skyrocketing costs. In contrast, less-regulated, technology-driven sectors see prices consistently fall, suggesting a correlation between intervention and price inflation.

By leveraging bulk purchasing, Gavi vaccinates children in developing countries for just $24 (compared to $1,300 in the US). This small investment saves one life for every 50-60 children vaccinated, yielding a cost-benefit ratio unmatched in healthcare or philanthropy.

Don't dismiss high-leverage but hard-to-measure interventions like government capacity building. Use "cost-effectiveness thinking": create back-of-the-envelope calculations and estimate success probabilities. This imposes quantitative discipline on qualitative decisions, avoiding the streetlight effect of only focusing on what's easily measured.

Government-administered aid programs are often highly inefficient, with significant overhead costs meaning only "cents on the dollar" reach the intended recipients. A more effective solution is to provide direct cash transfers or vouchers, empowering individuals to spend the money within the existing private market.

Billions spent on border security hardware are a less effective use of funds than foreign aid. The same resources invested in stabilizing migrant populations in the first countries they flee to—supporting local healthcare, jobs, and schools—could prevent onward migration to the West for a fraction of the cost.

An aid agency's budget is dwarfed by a host country's ministry spending. Therefore, instead of running parallel programs, the most impactful approach is "system strengthening": working directly with local government to integrate evidence and optimize how they allocate their own, much larger, budgets.

A child's chance of surviving cancer depends heavily on geography. The survival rate is 80% in high-income countries but plummets to 20% in low-income ones, not because the disease is different, but because of unequal access to care and systemic support.

Selling low-cost vaccines to organizations like Gavi isn't just charity for pharmaceutical companies. It creates massive economies of scale, lowering the cost of goods for their high-margin primary markets and increasing overall net profit, creating a powerful win-win incentive structure.